Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 18/20 | 0.57 |
| ▸ | JAK1 | P23458 | 12/20 | 0.57 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.51 |
| ▸ | AXL | P30530 | 1/20 | 0.49 |
| ▸ | MERTK | Q12866 | 1/20 | 0.49 |
| ▸ | TYK2 | P29597 | 2/20 | 0.47 |
| ▸ | JAK3 | P52333 | 2/20 | 0.47 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.47 |
| ▸ | PLK4 | O00444 | 1/20 | 0.47 |
| ▸ | STK25 | O00506 | 1/20 | 0.47 |
| ▸ | CIT | O14578 | 1/20 | 0.47 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.47 |
| ▸ | IKBKB | O14920 | 1/20 | 0.47 |
| ▸ | CASK | O14936 | 1/20 | 0.47 |
| ▸ | GAK | O14976 | 1/20 | 0.47 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.47 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.47 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.47 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1499310 | 0.93 | JAK2 (0.63) | JAK2JAK1TYRO3AXLMERTK | |
| SCHEMBL12832599 | 0.90 | TYRO3 (0.60) | JAK2JAK1TYRO3AXLMERTK | |
| SCHEMBL1498937 | 0.83 | TYRO3 (0.69) | JAK2JAK1TYRO3AXLMERTK | |
| SCHEMBL12832294 | 0.81 | TYRO3 (0.66) | JAK2JAK1TYRO3AXLMERTK | |
| SCHEMBL2085410 | 0.81 | TYRO3 (0.75) | JAK2JAK1TYRO3AXLMERTK | |
| SCHEMBL1498920 | 0.79 | TYRO3 (0.61) | JAK2JAK1TYRO3AXLMERTK | |
| SCHEMBL2086449 | 0.78 | TYRO3 (0.71) | JAK2JAK1TYRO3AXLMERTK | |
| SCHEMBL101686 | 0.76 | JAK2 (0.70) | JAK2JAK1TYRO3AXLMERTK | |
| SCHEMBL100966 | 0.76 | JAK2 (0.70) | JAK2JAK1TYRO3AXLMERTK | |
| SCHEMBL101072 | 0.76 | JAK2 (0.70) | JAK2JAK1TYRO3AXLMERTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011028685-A1 | HETEROCYCLIC DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-D]PYRIMIDINES AS JANUS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2011-03-10 | — | — | WO | disclosed |