Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYRO3 | Q06418 | 2/20 | 0.60 |
| ▸ | JAK2 | O60674 | 17/20 | 0.59 |
| ▸ | AXL | P30530 | 2/20 | 0.58 |
| ▸ | MERTK | Q12866 | 2/20 | 0.58 |
| ▸ | JAK1 | P23458 | 9/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1498937 | 0.93 | TYRO3 (0.69) | TYRO3JAK2AXLMERTKJAK1 | |
| SCHEMBL12832590 | 0.90 | JAK2 (0.57) | TYRO3JAK2AXLMERTKJAK1 | |
| SCHEMBL1499310 | 0.83 | JAK2 (0.63) | TYRO3JAK2AXLMERTKJAK1 | |
| SCHEMBL2088539 | 0.82 | TYRO3 (0.87) | TYRO3JAK2AXLMERTKJAK1 | |
| SCHEMBL1499175 | 0.81 | TYRO3 (0.72) | TYRO3JAK2AXLMERTKJAK1 | |
| SCHEMBL2088065 | 0.80 | TYRO3 (0.82) | TYRO3JAK2AXLMERTKJAK1 | |
| SCHEMBL1499194 | 0.79 | TYRO3 (0.67) | TYRO3JAK2AXLMERTKJAK1 | |
| SCHEMBL12832294 | 0.78 | TYRO3 (0.66) | TYRO3JAK2AXLMERTKJAK1 | |
| SCHEMBL12780565 | 0.77 | TYRO3 (0.69) | TYRO3JAK2AXLMERTKJAK1 | |
| SCHEMBL17957098 | 0.76 | JAK2 (0.68) | JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011028685-A1 | HETEROCYCLIC DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-D]PYRIMIDINES AS JANUS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2011-03-10 | — | — | WO | disclosed |