(-)-Cromakalim

(-)-Cromakalim

SCHEMBL12833

CC1(C)Oc2ccc(C#N)cc2[C@H](N2CCCC2=O)[C@H]1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ABCC9 O60706 9/20 1.00
ABCC8 Q09428 2/20 1.00
KCNJ11 Q14654 2/20 1.00
KCNJ8 Q15842 2/20 1.00
CYP1A2 P05177 1/20 1.00
CYP2D6 P10635 1/20 1.00
CYP2C9 P11712 1/20 1.00
CYP2C19 P33261 1/20 1.00
LMNA P02545 1/20 1.00
ABCB1 P08183 8/20 0.55
PDE4A P27815 1/20 0.53
PDE4B Q07343 1/20 0.53
PDE4C Q08493 1/20 0.53
PDE4D Q08499 1/20 0.53
KDM4E B2RXH2 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Levcromakalim SCHEMBL122344 1.00 ABCC9 (1.00) ABCC9ABCC8KCNJ11KCNJ8CYP1A2
(-)-Cromakalim SCHEMBL10644663 1.00 ABCC9 (1.00) ABCC9ABCC8KCNJ11KCNJ8CYP1A2
Levcromakalim SCHEMBL30059152 1.00 ABCC9 (1.00) ABCC9ABCC8KCNJ11KCNJ8CYP1A2
(-)-Cromakalim SCHEMBL24658941 1.00 ABCC9 (1.00) ABCC9ABCC8KCNJ11KCNJ8CYP1A2
Cromakalim SCHEMBL3312760 1.00 ABCC9 (1.00) ABCC9ABCC8KCNJ11KCNJ8CYP1A2
(-)-Cromakalim SCHEMBL25029865 1.00 ABCC9 (1.00) ABCC9ABCC8KCNJ11KCNJ8CYP1A2
(-)-Cromakalim SCHEMBL3771007 1.00 ABCC9 (1.00) ABCC9ABCC8KCNJ11KCNJ8CYP1A2
(-)-Cromakalim SCHEMBL29345689 1.00 ABCC9 (1.00) ABCC9ABCC8KCNJ11KCNJ8CYP1A2
Cromakalim SCHEMBL30110320 1.00 ABCC9 (1.00) ABCC9ABCC8KCNJ11KCNJ8CYP1A2
SCHEMBL10636063 0.97 ABCC9 (0.94) ABCC9ABCC8KCNJ11KCNJ8CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 3716 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260076961-A1 COMBINATION TREATMENTS Celex Oncology Innovations Limited (GB) 2026-03-19 US claimed
WO-2025078664-A1 TREATMENT OF METASTATIC OR INVASIVE BRAIN CANCER Celex Oncology Innovations Limited (GB) 2025-04-17 WO claimed
WO-2025064646-A1 COMPOSITIONS AND METHODS FOR WOUND HEALING AND HAIR GROWTH USING POLYELECTROLYTE COMPLEX (PEC) FILMS RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) 2025-03-27 WO claimed
EP-4486338-A2 TOPICAL OCULAR DELIVERY OF CROMAKALIM Qlaris Bio, Inc. (US) 2025-01-08 EP claimed
US-20240299405-A1 APPLICATION OF ATP POTASSIUM CHANNEL MODIFIER IN PREPARATION OF ANTI-DIABETIC NEPHROPATHY DRUG HANGZHOU QIAN BIOTECHNOLOGY LTD (CN) 2024-09-12 US claimed
US-20240285580-A1 COMPOSITIONS AND METHODS FOR EXTENDED RELEASE CROMAKALIM THERAPY QLARIS BIO, INC. (US) 2024-08-29 US claimed
EP-4384162-A1 COMPOSITIONS AND METHODS FOR EXTENDED RELEASE CROMAKALIM THERAPY Qlaris Bio, Inc. (US) 2024-06-19 EP claimed
WO-2024098043-A2 TOPICAL OCULAR DELIVERY OF CROMAKALIM QLARIS BIO, INC. (US) 2024-05-10 WO claimed
US-20240100123-A1 NOVEL AIMP1 PROTEIN FRAGMENT AND HAIR GROWTH-PROMOTING COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT CUREBIO THERAPEUTICS (KR) 2024-03-28 US claimed
US-11872263-B2 AIMP1 protein fragment and hair growth-promoting composition containing same as active ingredient CUREBIO THERAPEUTICS (KR) 2024-01-16 US claimed
WO-1988000822-A1 METHODS, COMPOSITIONS AND SOLUTIONS FOR TREATING ALOPECIA THE UPJOHN COMPANY (US) 1988-02-11 WO claimed
US-4719228-A Pharmaceutical composition Rawlins, David A. (GB) 1988-01-12 US claimed
EP-0207614-A2 Benzopyran compounds in the treatment of incontinence BEECHAM GROUP PLC (GB) 1987-01-07 EP claimed
EP-0076075-B1 PHARMACEUTICALLY ACTIVE BENZOPYRAN COMPOUNDS BEECHAM GROUP PLC (GB) 1986-11-20 EP claimed
EP-0176689-A2 Benzopyran compounds for the treatment of smooth muscles contraction BEECHAM GROUP PLC (GB) 1986-04-09 EP claimed
EP-0173848-A2 Benzopyran compounds for use in the cardiovascular system BEECHAM GROUP PLC (GB) 1986-03-12 EP claimed
EP-0163178-A2 Pharmaceutical composition BEECHAM GROUP PLC (GB) 1985-12-04 EP claimed
EP-0120428-A1 Benzopyran isomers BEECHAM GROUP PLC (GB) 1984-10-03 EP claimed
US-4446113-A HYPOTENSIVE AGENTS BEECHAM GROUP P.L.C. (GB) 1984-05-01 US claimed
EP-0076075-A1 Pharmaceutically active benzopyran compounds BEECHAM GROUP PLC (GB) 1983-04-06 EP claimed