Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 4/20 | 0.43 |
| ▸ | KDR | P35968 | 3/20 | 0.43 |
| ▸ | FLT1 | P17948 | 2/20 | 0.43 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.43 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.43 |
| ▸ | FLT4 | P35916 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12832825 | 0.92 | MAPK1 (0.39) | FGFR1KDRFLT1FGFR2FGFR4 | |
| SCHEMBL2134031 | 0.91 | FGFR1 (0.43) | FGFR1KDRFLT1FGFR2FGFR4 | |
| SCHEMBL12833097 | 0.87 | FGFR1 (0.42) | FGFR1KDRFLT1FGFR2FGFR4 | |
| SCHEMBL12832829 | 0.85 | ABL1 (0.39) | — | |
| SCHEMBL2133894 | 0.84 | FGFR1 (0.42) | FGFR1KDRFLT1FGFR2FGFR4 | |
| SCHEMBL2132162 | 0.83 | MAPK1 (0.39) | FGFR1KDRFLT1FGFR2FGFR4 | |
| SCHEMBL12833148 | 0.81 | MAPK1 (0.37) | — | |
| SCHEMBL12832824 | 0.79 | MAPK1 (0.41) | TSHR | |
| SCHEMBL12833143 | 0.78 | — | — | |
| SCHEMBL1505716 | 0.77 | FGFR1 (0.42) | FGFR1KDRFLT1FGFR2FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011024004-A1 | HETEROCYCLIC UREA DERIVATIVES USEFUL FOR TREATMENT OF BACTERIAL INFECTION | ASTRAZENECA AB (SE) | 2011-03-03 | — | — | WO | disclosed |
| WO-2009106885-A1 | HETEROCYCLIC UREA DERIVATIVES AND METHODS OF USE THEREOF-211 | ASTRAZENECA AB (SE) | 2009-09-03 | — | — | WO | disclosed |