Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CCND1 | P24385 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | CCND3 | P30281 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1509617 | 0.90 | GSK3B (0.54) | GSK3BMAPK14HTR7HDAC6CDK4 | |
| SCHEMBL12834022 | 0.88 | CHEK2 (0.47) | HDAC6HDAC3HDAC1HDAC8HDAC2 | |
| SCHEMBL14090502 | 0.84 | GSK3B (0.61) | GSK3BCDK4CCNA2CCND1CDK2 | |
| SCHEMBL14090462 | 0.81 | GSK3B (0.49) | GSK3BHDAC6CDK4CCNA2CCND1 | |
| SCHEMBL4964897 | 0.80 | CARM1 (0.51) | GSK3BHTR7HDAC6CDK4CCNA2 | |
| SCHEMBL12834549 | 0.80 | RAB9A (0.47) | — | |
| SCHEMBL1509636 | 0.80 | GSK3B (0.56) | GSK3BCDK4CCNA2CCND1CDK2 | |
| SCHEMBL12833837 | 0.80 | GSK3B (0.56) | GSK3BHDAC6CARM1HDAC3HDAC1 | |
| SCHEMBL14090464 | 0.78 | GSK3B (0.47) | GSK3BHDAC6CDK4CCNA2CCND1 | |
| SCHEMBL1509575 | 0.78 | CHEK2 (0.49) | GSK3BCARM1CHEK2BCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2298770-A1 | Heterocyclic compounds as TrkA modulators | ChemBridge Corporation (US) | 2011-03-23 | — | — | EP | disclosed |