Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 17/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | STAT3 | P40763 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL763610 | 0.90 | KIF11 (0.49) | KIF11LMNASTAT3MAPK1NPSR1 | |
| SCHEMBL8403289 | 0.89 | KIF11 (0.51) | KIF11LMNASTAT3MAPK1NPSR1 | |
| SCHEMBL763964 | 0.83 | KIF11 (0.63) | KIF11KDM4EMAPTLMNASTAT3 | |
| SCHEMBL11912465 | 0.82 | KIF11 (0.51) | KIF11LMNASTAT3 | |
| SCHEMBL763471 | 0.81 | KIF11 (0.61) | KIF11STAT3 | |
| SCHEMBL764038 | 0.81 | KIF11 (0.73) | KIF11 | |
| SCHEMBL764897 | 0.81 | KIF11 (0.64) | KIF11MAPTLMNA | |
| SCHEMBL22238474 | 0.81 | KIF11 (0.51) | KIF11KDM4EMAPTLMNA | |
| SCHEMBL763417 | 0.80 | KIF11 (0.60) | KIF11MAPTLMNA | |
| SCHEMBL8403169 | 0.80 | KIF11 (0.56) | KIF11KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2298304-A2 | Carboline derivatives useful in the treatment of cancer | PTC Therapeutics, Inc. (US) | 2011-03-23 | — | — | EP | disclosed |
| WO-2005089764-A9 | CARBOLINE DERIVATIVES USEFUL IN THE INHIBITION OF ANGIOGENESIS | PTC THERAPEUTICS INC (US) | 2007-09-13 | — | — | WO | disclosed |