Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23651944 | 0.86 | HPGD (0.53) | HPGDSMN1; SMN2ALDH1A1MAPTNPSR1 | |
| SCHEMBL12439651 | 0.83 | NPSR1 (0.66) | HPGDSMN1; SMN2ALDH1A1NPSR1KMT2A | |
| SCHEMBL12439350 | 0.81 | NPSR1 (0.62) | HPGDSMN1; SMN2ALDH1A1NPSR1KMT2A | |
| SCHEMBL1698458 | 0.81 | NPSR1 (0.68) | HPGDSMN1; SMN2ALDH1A1MAPTNPSR1 | |
| SCHEMBL27353316 | 0.79 | HPGD (0.49) | HPGDSMN1; SMN2ALDH1A1MAPTNPSR1 | |
| SCHEMBL23135469 | 0.79 | NPSR1 (0.65) | HPGDSMN1; SMN2ALDH1A1MAPTNPSR1 | |
| SCHEMBL19750483 | 0.79 | EPHX1 (0.59) | SMN1; SMN2MAPTNPSR1EPHX1EPHX2 | |
| SCHEMBL10587847 | 0.78 | ALDH1A1 (0.83) | HPGDSMN1; SMN2ALDH1A1MAPTNPSR1 | |
| SCHEMBL12858798 | 0.77 | NPSR1 (0.58) | HPGDSMN1; SMN2ALDH1A1NPSR1KMT2A | |
| SCHEMBL9125344 | 0.77 | HPGD (0.62) | HPGDSMN1; SMN2ALDH1A1MAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2292620-A2 | Fused-aryl and heteroaryl derivatives as modulators of metabolism and the prohylaxis and treatment of disorders related thereto | Arena Pharmaceuticals, Inc. (US) | 2011-03-09 | — | — | EP | disclosed |