SCHEMBL12835604

SCHEMBL12835604

CS(=O)(=O)c1ccc(N2NCc3c(OC4CCNCC4)ncnc32)cc1

nearest known ligand 0.47

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 20/20 0.47
CYP2C9 P11712 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12903935 0.82 GPR119 (0.55) GPR119
SCHEMBL12835415 0.79 GPR119 (0.48) GPR119CYP2C9
SCHEMBL12835597 0.79 GPR119 (0.49) GPR119CYP2C9
SCHEMBL12904514 0.78 GPR119 (0.49) GPR119CYP2C9
SCHEMBL12904176 0.77 GPR119 (0.47) GPR119CYP2C9
SCHEMBL12903937 0.76 GPR119 (0.50) GPR119CYP2C9
SCHEMBL12835414 0.76 RPS6KB1 (0.37) GPR119
SCHEMBL12835891 0.75 GPR119 (0.46) GPR119CYP2C9
SCHEMBL390767 0.73 GPR119 (0.68) GPR119CYP2C9
Hydrochloric Acid SCHEMBL1244784 0.73 GPR119 (0.67) GPR119CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2292620-A2 Fused-aryl and heteroaryl derivatives as modulators of metabolism and the prohylaxis and treatment of disorders related thereto Arena Pharmaceuticals, Inc. (US) 2011-03-09 EP disclosed
EP-2287166-A2 Fused-aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto Arena Pharmaceuticals, Inc. (US) 2011-02-23 EP disclosed
EP-2287165-A2 Fused-aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto Arena Pharmaceuticals, Inc. (US) 2011-02-23 EP disclosed