SCHEMBL12836892

SCHEMBL12836892

CC(=O)CC(C)(O)C(C)=O

nearest known ligand 0.40

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.40
TSHR P16473 2/20 0.40
HMGCR P04035 1/20 0.39
CHRM1 P11229 1/20 0.39
TBXA2R P21731 1/20 0.39
ADRA1A P35348 1/20 0.39
TET2 Q6N021 1/20 0.36
TDP1 Q9NUW8 1/20 0.35
TRPA1 O75762 1/20 0.33
GAA P10253 1/20 0.33
CYP2D6 P10635 1/20 0.32
CYP2C19 P33261 1/20 0.32
HIF1A Q16665 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2996525 0.80 TET2 (0.56) ALDH1A1TSHRHMGCRCHRM1TBXA2R
Hydrochloric Acid SCHEMBL11581270 0.78 TET2 (0.54) ALDH1A1TSHRHMGCRCHRM1TBXA2R
SCHEMBL13040821 0.76 TDP1 (0.43) ALDH1A1TSHRHMGCRCHRM1TBXA2R
SCHEMBL1536952 0.75 HMGCR (0.43) ALDH1A1TSHRHMGCRCHRM1TBXA2R
SCHEMBL7041938 0.75 HMGCR (0.58) ALDH1A1TSHRHMGCRCHRM1TBXA2R
SCHEMBL28494 0.75
SCHEMBL12835664 0.74 HMGCR (0.33) ALDH1A1TSHRHMGCRCHRM1TBXA2R
SCHEMBL10308621 0.74 ALDH1A1 (0.35) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
SCHEMBL13078567 0.74 ALDH1A1 (0.35) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
SCHEMBL124447 0.73

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011033296-A1 PRODRUGS OF GUANFACINE SHIRE LLC (US) 2011-03-24 WO disclosed
WO-2010112942-A1 NOVEL DICARBOXYLIC ACID LINKED AMINO ACID AND PEPTIDE PRODRUGS OF OPIOIDS AND USES THEREOF SHIRE LLC (US) 2010-10-07 WO disclosed