SCHEMBL12840308

SCHEMBL12840308

Nc1ccc2c(c1)CCc1nc(NC(=O)c3ccccc3)c(-c3ccc(O)cc3)nc1-2

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TOP2A P11388 1/20 0.43
FGFR1 P11362 1/20 0.41
FGFR2 P21802 1/20 0.41
FGFR3 P22607 1/20 0.41
CYP1A2 P05177 3/20 0.40
CYP2C19 P33261 3/20 0.40
CYP3A4 P08684 2/20 0.40
GAA P10253 2/20 0.40
MAPT P10636 4/20 0.37
CYP2C9 P11712 2/20 0.37
HDAC1 Q13547 3/20 0.37
TYR P14679 1/20 0.37
DEGS1 O15121 1/20 0.37
CDK2 P24941 1/20 0.37
GSK3A P49840 1/20 0.37
GSK3B P49841 1/20 0.37
MEN1 O00255 3/20 0.36
KMT2A Q03164 3/20 0.36
HTT P42858 3/20 0.36
KDM4E B2RXH2 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12838754 0.94 CYP1A2 (0.43) CYP1A2CYP2C19CYP3A4GAAMAPT
SCHEMBL12839737 0.92 FGFR1 (0.43) FGFR1FGFR2FGFR3CYP1A2CYP2C19
SCHEMBL12839433 0.89 TYR (0.42) FGFR1FGFR2FGFR3CYP1A2CYP2C19
SCHEMBL12840192 0.88 DHODH (0.43) FGFR1FGFR2FGFR3CYP1A2CYP2C19
SCHEMBL12839100 0.87 CYP1A2 (0.50) FGFR1FGFR2FGFR3CYP1A2CYP2C19
SCHEMBL12840675 0.87 TOP2A (0.41) TOP2ATYRCDK2GSK3AGSK3B
SCHEMBL12840640 0.87 TOP2A (0.41) TOP2AGAAMAPTCYP2C9DEGS1
SCHEMBL12840247 0.85 MAPT (0.52) CYP1A2CYP2C19CYP3A4MAPTCYP2C9
SCHEMBL12840708 0.85 HCAR2 (0.42) TOP2ACYP2C9LMNA
SCHEMBL13068338 0.85 CDK2 (0.41) TOP2AGAACYP2C9DEGS1CDK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110070656-A1 Fluorescent Proteins JNC CORPORATION (JP) 2011-03-24 US disclosed
EP-1666488-B1 FLUORESCENT PROTEIN CHISSO CORP (JP) 2010-11-17 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110070656-A1 Fluorescent Proteins CACYBP, CHLSN, LCP2 TOP2A 3075/4885FGFR1 3660/4885FGFR2 4317/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.