SCHEMBL12839737

SCHEMBL12839737

O=C(Nc1nc2c(nc1-c1ccc(O)cc1)-c1ccc(O)cc1CC2)c1ccccc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FGFR1 P11362 1/20 0.43
FGFR2 P21802 1/20 0.43
FGFR3 P22607 1/20 0.43
TYR P14679 1/20 0.42
MEN1 O00255 3/20 0.41
KMT2A Q03164 3/20 0.41
CYP1A2 P05177 2/20 0.41
CYP3A4 P08684 2/20 0.41
CYP2C19 P33261 2/20 0.41
GAA P10253 2/20 0.41
DEGS1 O15121 1/20 0.40
HCAR2 Q8TDS4 3/20 0.39
CYP2C9 P11712 3/20 0.39
CYP2C8 P10632 1/20 0.39
MAPT P10636 3/20 0.38
HTT P42858 3/20 0.38
ADORA3 P0DMS8 3/20 0.38
KDM4E B2RXH2 2/20 0.38
LMNA P02545 2/20 0.38
POLB P06746 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12839433 0.97 TYR (0.42) FGFR1FGFR2FGFR3TYRMEN1
SCHEMBL12840308 0.92 TOP2A (0.43) FGFR1FGFR2FGFR3TYRMEN1
SCHEMBL12840192 0.92 DHODH (0.43) FGFR1FGFR2FGFR3CYP1A2CYP3A4
SCHEMBL12839100 0.91 CYP1A2 (0.50) FGFR1FGFR2FGFR3MEN1KMT2A
SCHEMBL12840247 0.89 MAPT (0.52) MEN1KMT2ACYP1A2CYP3A4CYP2C19
SCHEMBL12839735 0.86 TYR (0.45) FGFR1FGFR2FGFR3TYRMEN1
SCHEMBL12840536 0.86 TSHR (0.41) GAAHCAR2CYP2C9CYP2C8MAPT
SCHEMBL12838663 0.85 MAPT (0.45) TYRMEN1KMT2ACYP1A2CYP3A4
SCHEMBL12840579 0.85 IKBKB (0.41) MEN1KMT2AGAADEGS1HCAR2
SCHEMBL12840566 0.85 HSD17B1 (0.37) TYRMEN1KMT2ACYP3A4HCAR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110070656-A1 Fluorescent Proteins JNC CORPORATION (JP) 2011-03-24 US disclosed
EP-1666488-B1 FLUORESCENT PROTEIN CHISSO CORP (JP) 2010-11-17 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110070656-A1 Fluorescent Proteins CACYBP, CHLSN, LCP2 FGFR1 3660/4885FGFR2 4317/4885FGFR3 4223/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.