SCHEMBL12840398

SCHEMBL12840398

O=C(Cc1ccc(F)cc1)Nc1ncc(-c2ccc(O)cc2)nc1CCc1ccccc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.45
DEGS1 O15121 1/20 0.44
MAPK14 Q16539 4/20 0.43
RAB9A P51151 2/20 0.43
MEN1 O00255 1/20 0.43
NPC1 O15118 1/20 0.43
MAPK1 P28482 1/20 0.42
TMIGD3 P0DMS9 1/20 0.41
ALDH1A1 P00352 1/20 0.41
GSK3B P49841 1/20 0.41
GLS O94925 1/20 0.41
ATR Q13535 1/20 0.41
PRKACA P17612 1/20 0.41
ROCK1 Q13464 1/20 0.41
HCAR2 Q8TDS4 2/20 0.40
WNT3A P56704 1/20 0.40
CYP2C8 P10632 1/20 0.40
CYP2C9 P11712 1/20 0.40
MET P08581 1/20 0.40
LMNA P02545 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12839144 1.00 KMT2A (0.45) KMT2ADEGS1MAPK14RAB9AMEN1
SCHEMBL2508250 0.95 DEGS1 (0.48) KMT2ADEGS1RAB9AMEN1NPC1
SCHEMBL12840006 0.95 MAPK14 (0.47) KMT2AMAPK14RAB9AMEN1NPC1
SCHEMBL12838993 0.94 TMIGD3 (0.47) KMT2AMAPK14RAB9AMEN1NPC1
SCHEMBL12838875 0.94 DEGS1 (0.49) KMT2ADEGS1RAB9AMEN1NPC1
SCHEMBL12839147 0.91 NPY5R (0.44) KMT2AMAPK14RAB9AMEN1NPC1
SCHEMBL12839145 0.91 MAPK14 (0.45) KMT2AMAPK14RAB9AMEN1NPC1
SCHEMBL12839149 0.91 KMT2A (0.44) KMT2AMAPK14RAB9AMEN1NPC1
SCHEMBL12838494 0.91 KMT2A (0.46) KMT2ADEGS1MAPK14RAB9AMEN1
SCHEMBL12838880 0.91 KMT2A (0.46) KMT2ADEGS1MAPK14RAB9AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110070656-A1 Fluorescent Proteins JNC CORPORATION (JP) 2011-03-24 US disclosed
EP-1666488-B1 FLUORESCENT PROTEIN CHISSO CORP (JP) 2010-11-17 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110070656-A1 Fluorescent Proteins CACYBP, CHLSN, LCP2 KMT2A 4653/4885DEGS1 4476/4885MAPK14 4682/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.