SCHEMBL12839149

SCHEMBL12839149

O=C(Cc1ccc(Br)cc1)Nc1ncc(-c2ccc(F)cc2)nc1CCc1ccccc1

nearest known ligand 0.47

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.44
MAPK14 Q16539 4/20 0.43
TMIGD3 P0DMS9 1/20 0.41
RAB9A P51151 2/20 0.40
ALDH1A1 P00352 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
MEN1 O00255 2/20 0.40
NPC1 O15118 1/20 0.40
GSK3B P49841 1/20 0.40
ATR Q13535 1/20 0.40
PRKACA P17612 1/20 0.40
ROCK1 Q13464 1/20 0.40
WNT3A P56704 1/20 0.40
EGFR P00533 2/20 0.39
ERBB2 P04626 2/20 0.39
CCNE1 P24864 1/20 0.39
CDK2 P24941 1/20 0.39
CDK5 Q00535 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12840006 0.94 MAPK14 (0.47) KMT2AMAPK14TMIGD3RAB9AALDH1A1
SCHEMBL12838993 0.93 TMIGD3 (0.47) KMT2AMAPK14TMIGD3RAB9AALDH1A1
SCHEMBL12839001 0.93 TMIGD3 (0.47) KMT2ATMIGD3RAB9AL3MBTL1MEN1
SCHEMBL12840400 0.91 DEGS1 (0.44) KMT2ATMIGD3RAB9AL3MBTL1MEN1
SCHEMBL12840398 0.91 KMT2A (0.45) KMT2AMAPK14TMIGD3RAB9AALDH1A1
SCHEMBL12839144 0.91 KMT2A (0.45) KMT2AMAPK14TMIGD3RAB9AALDH1A1
SCHEMBL12838497 0.91 KMT2A (0.45) KMT2AMAPK14TMIGD3RAB9AALDH1A1
SCHEMBL12839147 0.90 NPY5R (0.44) KMT2AMAPK14TMIGD3RAB9AALDH1A1
SCHEMBL12839145 0.90 MAPK14 (0.45) KMT2AMAPK14TMIGD3RAB9AALDH1A1
SCHEMBL12840483 0.90 GLS (0.41) KMT2ATMIGD3RAB9AL3MBTL1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110070656-A1 Fluorescent Proteins JNC CORPORATION (JP) 2011-03-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110070656-A1 Fluorescent Proteins CACYBP, CHLSN, LCP2 KMT2A 4653/4885MAPK14 4682/4885TMIGD3 1782/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.