SCHEMBL12840508

SCHEMBL12840508

CCc1nc(-c2ccc(N)cc2)cnc1NC(C)=O

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PIK3CA P42336 4/20 0.46
MAPK1 P28482 2/20 0.46
MAPK8 P45983 2/20 0.46
MAPK9 P45984 2/20 0.46
MAPK10 P53779 2/20 0.46
ATR Q13535 8/20 0.42
PRKDC P78527 1/20 0.40
PARP1 P09874 1/20 0.40
IKBKB O14920 1/20 0.39
FYN P06241 1/20 0.38
ADORA3 P0DMS8 1/20 0.38
ATM Q13315 1/20 0.38
KDM4E B2RXH2 2/20 0.38
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38
PRNP P04156 1/20 0.38
POLB P06746 1/20 0.38
GAA P10253 1/20 0.38
ALDH1A1 P00352 1/20 0.38
MAPT P10636 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12838909 0.88 MAPK1 (0.46) PIK3CAMAPK1MAPK8MAPK9MAPK10
SCHEMBL12839148 0.87 ADORA3 (0.48) MAPK1ATRADORA3KDM4EMEN1
SCHEMBL12840368 0.86 IKBKB (0.49) MAPK1ATRPRKDCIKBKBADORA3
SCHEMBL12839672 0.86 ATR (0.43) PIK3CAMAPK1MAPK8MAPK9MAPK10
SCHEMBL12838956 0.85 ADORA3 (0.50) MAPK1ATRPRKDCPARP1FYN
SCHEMBL12840518 0.84 PTPN1 (0.48) PIK3CAMAPK1MAPK8MAPK9MAPK10
SCHEMBL12840491 0.84 MAPK1 (0.43) PIK3CAMAPK1MAPK8MAPK9MAPK10
SCHEMBL13068289 0.84 ATR (0.46) PIK3CAMAPK1MAPK8MAPK9MAPK10
SCHEMBL12839223 0.84 ATR (0.45) PIK3CAMAPK1MAPK8MAPK9MAPK10
SCHEMBL12839237 0.83 ATR (0.44) PIK3CAMAPK1MAPK8MAPK9MAPK10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110070656-A1 Fluorescent Proteins JNC CORPORATION (JP) 2011-03-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110070656-A1 Fluorescent Proteins CACYBP, CHLSN, LCP2 PIK3CA 4787/4885MAPK1 4830/4885MAPK8 4860/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.