Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 2/20 | 0.39 |
| ▸ | CDK14 | O94921 | 1/20 | 0.39 |
| ▸ | CCNY | Q8ND76 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.38 |
| ▸ | BTK | Q06187 | 4/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CDK7 | P50613 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.37 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 3/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | ITK | Q08881 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26018895 | 0.90 | JAK3 (0.42) | JAK3CDK14CCNYHDAC1HDAC2 | |
| SCHEMBL12841131 | 0.85 | JAK3 (0.42) | JAK3CDK14CCNYHDAC1HDAC2 | |
| SCHEMBL17244275 | 0.85 | HDAC1 (0.41) | JAK3CDK14CCNYHDAC1HDAC2 | |
| SCHEMBL462207 | 0.85 | ALDH1A1 (0.44) | JAK3CDK14CCNYHDAC1HDAC2 | |
| SCHEMBL24244462 | 0.82 | MAPT (0.41) | JAK3CDK14CCNYEGFR | |
| SCHEMBL18455437 | 0.82 | JAK3 (0.41) | JAK3EGFR | |
| SCHEMBL30072903 | 0.82 | JAK3 (0.41) | JAK3EGFR | |
| SCHEMBL18909694 | 0.82 | BTK (0.39) | JAK3CDK14CCNYHDAC1HDAC2 | |
| SCHEMBL19054740 | 0.82 | BTK (0.39) | JAK3CDK14CCNYHDAC1HDAC2 | |
| SCHEMBL19190232 | 0.81 | JAK3 (0.41) | JAK3EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011034907-A2 | PROTEIN KINASE CONJUGATES AND INHIBITORS | AVILA THERAPEUTICS, INC. (US) | 2011-03-24 | — | — | WO | disclosed |