Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 11/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 9/20 | 0.51 |
| ▸ | KDR | P35968 | 9/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.51 |
| ▸ | ABL1 | P00519 | 7/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 7/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 7/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.51 |
| ▸ | HDAC10 | Q969S8 | 7/20 | 0.51 |
| ▸ | HDAC11 | Q96DB2 | 7/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.51 |
| ▸ | HDAC9 | Q9UKV0 | 7/20 | 0.51 |
| ▸ | HDAC5 | Q9UQL6 | 7/20 | 0.51 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.42 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.42 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13970137 | 0.93 | HDAC1 (0.55) | HDAC1PDGFRBKDRHDAC3ABL1 | |
| SCHEMBL12847465 | 0.88 | HDAC1 (0.45) | HDAC1PDGFRBKDRHDAC3ABL1 | |
| SCHEMBL13969900 | 0.88 | PDGFRB (0.48) | HDAC1PDGFRBKDRHDAC3ABL1 | |
| SCHEMBL13969934 | 0.86 | GAA (0.61) | HDAC1CACNA1BAPBA1KLF5GAA | |
| SCHEMBL13985098 | 0.85 | GAA (0.51) | HDAC1PDGFRBKDRHDAC3ABL1 | |
| SCHEMBL12790556 | 0.84 | HDAC1 (0.56) | HDAC1PDGFRBKDRHDAC3ABL1 | |
| SCHEMBL13984933 | 0.81 | HDAC1 (0.42) | HDAC1PDGFRBKDRHDAC3ABL1 | |
| SCHEMBL13970134 | 0.80 | HDAC1 (0.42) | HDAC1PDGFRBKDRHDAC3ABL1 | |
| SCHEMBL3675364 | 0.78 | MAPT (0.65) | HDAC1CACNA1BAPBA1KLF5GAA | |
| SCHEMBL13985019 | 0.77 | CACNA1B (0.55) | ABL1CACNA1BAPBA1KLF5GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110052527-A1 | IMIDAZOPYRIDINYL THIAZOLYL HISTONE DEACETYLASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2011-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110052527-A1 | IMIDAZOPYRIDINYL THIAZOLYL HISTONE DEACETYLASE INHIBITORS | HDAC1, HDAC8, HDAC5 | HDAC1 1/4885PDGFRB 3094/4885KDR 4100/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.