Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR142 | Q7Z601 | 2/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 7/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 7/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 7/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 7/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 7/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 7/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.35 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.35 |
| ▸ | NR2E1 | Q9Y466 | 3/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.34 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.33 |
| ▸ | LDLR | P01130 | 1/20 | 0.33 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12848568 | 0.90 | MAPT (0.34) | MAPTSTIM1ORAI1ALDH1A1 | |
| SCHEMBL12848749 | 0.90 | MAPT (0.34) | GPR142MAPTSTIM1ORAI1KDM4E | |
| SCHEMBL12848566 | 0.90 | MAP3K5 (0.35) | MAPTSTIM1ORAI1KDM4EALDH1A1 | |
| SCHEMBL12848854 | 0.89 | MAPT (0.34) | MAPTSTIM1ORAI1 | |
| SCHEMBL12848966 | 0.89 | MAPT (0.33) | MAPTSTIM1ORAI1ALDH1A1 | |
| SCHEMBL12848567 | 0.89 | MAP3K5 (0.39) | — | |
| SCHEMBL12848915 | 0.88 | MAPT (0.36) | MAPTSTIM1ORAI1KDM4EALDH1A1 | |
| SCHEMBL12848856 | 0.88 | MAPT (0.33) | USP30MAPTSTIM1ORAI1KDM4E | |
| SCHEMBL12848751 | 0.87 | HTR2A (0.35) | MAPTSTIM1ORAI1ALDH1A1 | |
| SCHEMBL12848964 | 0.87 | MAPT (0.33) | MAPTSTIM1ORAI1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110052643-A1 | COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2011-03-03 | — | — | US | disclosed |
| WO-2009089305-A1 | COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2009-07-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110052643-A1 | COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | TSLP, NFATC1, IL5 | GPR142 1957/4885PSEN1 3587/4885PSEN2 3530/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.