Sugi Predict

Sugi Predict / Targets / TSLP

TSLP

Thymic stromal lymphopoietin · Q969D9 · TSLP on Sugi Atlas →

2,717 patent compounds predicted against TSLP, 1,677 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL14550196 SCHEMBL14550196 0.55 20/20
SCHEMBL14271540 SCHEMBL14271540 0.57 19/20
SCHEMBL14550576 SCHEMBL14550576 0.54 19/20
SCHEMBL14552176 SCHEMBL14552176 0.55 18/20
SCHEMBL13253803 SCHEMBL13253803 0.59 17/20
SCHEMBL15705738 SCHEMBL15705738 0.59 17/20
SCHEMBL16340440 SCHEMBL16340440 0.54 17/20
SCHEMBL13857316 SCHEMBL13857316 0.53 17/20
Eptifibatide Eptifibatide (SCHEMBL5577779) 0.49 17/20
SCHEMBL7855681 SCHEMBL7855681 0.59 16/20
SCHEMBL13253812 SCHEMBL13253812 0.54 16/20
SCHEMBL13857314 SCHEMBL13857314 0.53 16/20
SCHEMBL13857317 SCHEMBL13857317 0.52 16/20
SCHEMBL13857313 SCHEMBL13857313 0.51 16/20
SCHEMBL13253828 SCHEMBL13253828 0.51 16/20
SCHEMBL16340416 SCHEMBL16340416 0.57 15/20
SCHEMBL16340459 SCHEMBL16340459 0.53 15/20
SCHEMBL13587615 SCHEMBL13587615 0.49 15/20
SCHEMBL16340429 SCHEMBL16340429 0.53 14/20
SCHEMBL16340448 SCHEMBL16340448 0.53 14/20

Clinical trials — most relevant to TSLP by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
BenRalizumab Effect on Airway Remodeling in Severe asTHma PHASE4UNKNOWN
Prevention of Asthma and Allergy by Probiotic Lactobacillus GG PHASE4COMPLETED
th2 Modulation CRSwNP PHASE4UNKNOWN
The Effect of Allergen Immunotherapy on Anti-viral Immunity in Patients With Allergic Asthma PHASE4COMPLETED
Tezepelumab on Airway Structure and Function in Patients With Uncontrolled Moderate-to-severe Asthma PHASE3COMPLETED
Observation on the Efficacy and Mechanism of SLIT With Dust Mite Allergen for PAR PHASE2/PHASE3UNKNOWN
Opening the Black Box on Tezepelumab's Effect on Chronic Rhinosinusitis With Severe Asthma PHASE3NOT_YET_RECRUITING
Study of Thymopentin in Patients After Curative Resection of Small Hepatocellular Carcinoma PHASE3UNKNOWN
Montelukast for Early Life Wheezing PHASE2/PHASE3COMPLETED
Tezepelumab in Allergic Rhinitis and Asthma Study (TEZARS) PHASE2ACTIVE_NOT_RECRUITING
Study of Stapokibart Injection in Patients With Allergic Rhinitis PHASE2RECRUITING
Clinical Response to Rhinovirus Challenge PHASE2COMPLETED
A Multi-dose Study on the Safety and Efficacy of Self-administered Intranasal AD17002 Treatment for Eosinophilic Asthma PHASE2NOT_YET_RECRUITING
Anti-CRLF2-R/TSLPR Chimeric Antigen Receptor T Cells (TSLPR-CART) in Participants With Recurrent or Refractory CRLF2-R/TSLPR-Overexpressing B-Cell Acute Lymphoblastic Leukemia (B-ALL) PHASE1NOT_YET_RECRUITING
Safety and Efficacy of ADSTEM Inj. in Patients With Moderately Subacute and Chronic Atopic Dermatitis PHASE1COMPLETED
The Inflammatory Profile of Exacerbations in Patients With Severe Asthma Receiving Tezepelumab: The TezEx Study nanNOT_YET_RECRUITING
Efficacy of Mepolizumab in Severe Asthmatics on a Long Term (MESILICO) nanUNKNOWN
COVID-19 Infection and Epithelial Cell Markers nanUNKNOWN
Using Exercise-testing to Explore Patient Differences in Severe Asthma nanACTIVE_NOT_RECRUITING
Tezspire Cardiac Events PASS nanRECRUITING
Using NLP and Neural Networks to Autonomously Identify Severe Asthma and Determine Study Eligibility in a Large Healthcare System nanACTIVE_NOT_RECRUITING
Refractory Asthma Stratification Programme (RASP) Bronchoscopy Study nanUNKNOWN
Effects of Intranasal Corticosteroid and Montelukast On Nasal Allergen Challenges* nanCOMPLETED
Kinetics of Nasal Cytokine Responses to Mechanical Stimulation nanCOMPLETED
Histamine Pharmacogenetics in Children With Atopic Dermatitis nanCOMPLETED
Effect of Biologicals on Alternative Functions of Eosinophils in Severe Asthma nanACTIVE_NOT_RECRUITING
Lung-Resident Memory Th2 Cells in Asthma nanACTIVE_NOT_RECRUITING
T Cell Cytokine Changes During IL-4 Receptor Treatment for Asthma nanCOMPLETED
Phenotyping Circulating and Lung Resident Eosinophils in Severe Asthma (P-CLESA) nanUNKNOWN
Evaluation of Biomarkers of Atopic Dermatitis in Pediatric Patients (PEDISTAD BIOMARKER STUDY) nanACTIVE_NOT_RECRUITING

Related proteins — ESM-2 sequence neighbours (a TSLP binder may also engage these)

ProteinNameSimilarity
A0A1B0GVD1 — 0.999 A0A1B0GVD1 →
C0HMB7 — 0.998 C0HMB7 →
Q5QT17 — 0.996 Q5QT17 →
Q9GJY2 — 0.996 Q9GJY2 →
P52526 — 0.996 P52526 →
P53964 — 0.996 P53964 →
Q64244 — 0.995 Q64244 →
A8R0V4 — 0.995 A8R0V4 →
O42654 — 0.995 O42654 →
Q01032 — 0.995 Q01032 →
P17466 — 0.995 P17466 →
P36357 — 0.995 P36357 →
P0CAE7 — 0.994 P0CAE7 →
P60505 — 0.994 P60505 →
Q00997 — 0.994 Q00997 →
Q62574 — 0.994 Q62574 →
Q0E589 — 0.994 Q0E589 →
O65107 — 0.994 O65107 →
P18570 — 0.994 P18570 →
P03319 — 0.994 P03319 →
A0A7H0DNG7 — 0.993 A0A7H0DNG7 →
P17071 — 0.993 P17071 →
Q12079 — 0.993 Q12079 →
P35940 — 0.993 P35940 →
P17803 — 0.993 P17803 →
Q9E6N5 — 0.993 Q9E6N5 →
P0DPW7 — 0.993 P0DPW7 →
P30889 — 0.993 P30889 →
A7WNB0 — 0.993 A7WNB0 →
Q5ZK14 — 0.993 Q5ZK14 →