Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12848580 | 0.83 | NOTUM (0.44) | NOTUMKDM4EMAPTALDH1A1MEN1 | |
| SCHEMBL12848882 | 0.82 | MEN1 (0.48) | NOTUMPIK3CAKDM4EMAPTALDH1A1 | |
| SCHEMBL12848734 | 0.80 | NOTUM (0.41) | NOTUMPIK3CAKDM4EMAPTALDH1A1 | |
| SCHEMBL988576 | 0.79 | NOTUM (0.56) | NOTUMPIK3CAKDM4EALDH1A1GAA | |
| SCHEMBL988463 | 0.79 | NOTUM (0.70) | NOTUMPIK3CAKDM4EALDH1A1GAA | |
| SCHEMBL12848729 | 0.78 | KDM4E (0.41) | NOTUMKDM4EMAPTALDH1A1MEN1 | |
| SCHEMBL4109994 | 0.78 | NOTUM (0.55) | NOTUMPIK3CAKDM4EALDH1A1GAA | |
| SCHEMBL987951 | 0.78 | NOTUM (0.55) | NOTUMPIK3CAKDM4EALDH1A1GAA | |
| SCHEMBL12719326 | 0.78 | KDM4E (0.56) | NOTUMPIK3CAKDM4EALDH1A1GAA | |
| SCHEMBL4109996 | 0.75 | NOTUM (0.50) | NOTUMPIK3CAKDM4EMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110052643-A1 | COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2011-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110052643-A1 | COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | TSLP, NFATC1, IL5 | NOTUM 2573/4885PIK3CA 1831/4885KDM4E 2836/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.