Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 17/20 | 0.51 |
| ▸ | CDK9 | P50750 | 13/20 | 0.51 |
| ▸ | CCNK | O75909 | 4/20 | 0.51 |
| ▸ | CDK14 | O94921 | 1/20 | 0.51 |
| ▸ | CDK1 | P06493 | 1/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.51 |
| ▸ | CDK16 | Q00536 | 1/20 | 0.51 |
| ▸ | CDK17 | Q00537 | 1/20 | 0.51 |
| ▸ | CDK18 | Q07002 | 1/20 | 0.51 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12849963 | 1.00 | CCNT1 (0.51) | CCNT1CDK9CCNKCDK14CDK1 | |
| SCHEMBL12850537 | 0.91 | CCNT1 (0.60) | CCNT1CDK9CCNKCDK14CDK1 | |
| SCHEMBL12850334 | 0.91 | CCNT1 (0.60) | CCNT1CDK9CCNKCDK14CDK1 | |
| SCHEMBL12466260 | 0.89 | CCNT1 (0.63) | CCNT1CDK9CCNKCDK14CDK1 | |
| SCHEMBL12466256 | 0.89 | CCNT1 (0.63) | CCNT1CDK9CCNKCDK14CDK1 | |
| SCHEMBL12850267 | 0.88 | CDK9 (0.46) | CCNT1CDK9CCNKCDK14CDK1 | |
| SCHEMBL12850288 | 0.87 | CCNT1 (0.47) | CCNT1CDK9CCNK | |
| SCHEMBL12850276 | 0.86 | CCNT1 (0.44) | CCNT1CDK9CCNKCDK14CDK1 | |
| SCHEMBL12849861 | 0.84 | CCNT1 (0.68) | CCNT1CDK9CCNKCDK14CDK1 | |
| SCHEMBL12850652 | 0.81 | CCNT1 (0.49) | CCNT1CDK9CCNKCDK14CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012101062-A1 | SUBSTITUTED BI-HETEROARYL COMPOUNDS AS CDK9 INHIBITORS AND THEIR USES | NOVARTIS AG (CH) | 2012-08-02 | — | — | WO | disclosed |