Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 10/20 | 1.00 |
| ▸ | HDAC6 | Q9UBN7 | 10/20 | 1.00 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.61 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.61 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.61 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.61 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.61 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.61 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.61 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.61 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.61 |
| ▸ | USP2 | O75604 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | MMP3 | P08254 | 1/20 | 0.59 |
| ▸ | MMP7 | P09237 | 1/20 | 0.59 |
| ▸ | MMP10 | P09238 | 1/20 | 0.59 |
| ▸ | MMP12 | P39900 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3969090 | 0.86 | HDAC1 (0.76) | HDAC1HDAC6GAAUSP2POLB | |
| SCHEMBL12850475 | 0.84 | HDAC1 (1.00) | HDAC1HDAC6HDAC10HDAC2HDAC8 | |
| SCHEMBL6789890 | 0.82 | MMP12 (0.69) | HDAC1HDAC6MMP3MMP7MMP10 | |
| SCHEMBL6789886 | 0.82 | MMP12 (0.69) | HDAC1HDAC6MMP3MMP7MMP10 | |
| SCHEMBL6791133 | 0.82 | MMP12 (0.69) | HDAC1HDAC6MMP3MMP7MMP10 | |
| SCHEMBL6790949 | 0.82 | MMP12 (0.69) | HDAC1HDAC6MMP3MMP7MMP10 | |
| SCHEMBL6795281 | 0.82 | MMP12 (0.69) | HDAC1HDAC6MMP3MMP7MMP10 | |
| SCHEMBL6790299 | 0.81 | MMP12 (0.75) | HDAC1HDAC6MMP3MMP7MMP10 | |
| SCHEMBL6785972 | 0.81 | MMP12 (0.72) | HDAC1HDAC6MMP3MMP7MMP10 | |
| SCHEMBL10040282 | 0.80 | MEN1 (0.67) | HDAC1HDAC6GAATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2670733-B1 | N-HYDROXYBENZAMIDE DERIVATIVES AS HDAC INHIBITORS AND THERAPEUTIC METHODS USING THE SAME | UNIV ILLINOIS (US) | 2019-04-10 | — | — | EP | disclosed |
| EP-2670733-B1 | N-HYDROXYBENZAMIDE DERIVATIVES AS HDAC INHIBITORS AND THERAPEUTIC METHODS USING THE SAME | UNIV ILLINOIS (US) | 2019-04-10 | — | — | EP | disclosed |
| US-RE47009-E1 | HDAC inhibitors and therapeutic methods using the same | THE CHILDREN'S HOSPITAL OF PHILADELPHIA (US) | 2018-08-28 | — | — | US | disclosed |
| US-9249087-B2 | HDAC inhibitors and therapeutic methods using the same | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2016-02-02 | — | — | US | disclosed |
| US-20140128408-A1 | HDAC INHIBITORS AND THERAPEUTIC METHODS USING THE SAME | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2014-05-08 | — | — | US | disclosed |
| US-20140128408-A1 | HDAC INHIBITORS AND THERAPEUTIC METHODS USING THE SAME | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2014-05-08 | — | — | US | disclosed |
| US-20140128408-A1 | HDAC INHIBITORS AND THERAPEUTIC METHODS USING THE SAME | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2014-05-08 | — | — | US | disclosed |
| WO-2012106343-A2 | HDAC INHIBITORS AND THERAPEUTIC METHODS USING THE SAME | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2012-08-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140128408-A1 | HDAC INHIBITORS AND THERAPEUTIC METHODS USING THE SAME | HDAC1, HDAC9, HDAC8 | HDAC1 1/4885HDAC6 9/4885GAA 2309/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.