MMP12 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL314397	1.00	18/20
SCHEMBL315035	0.77	18/20
SCHEMBL316169	0.77	17/20
SCHEMBL316301	0.87	15/20
SCHEMBL315452	0.86	15/20
SCHEMBL314725	0.74	15/20
SCHEMBL315368	1.00	13/20
SCHEMBL315453	0.64	13/20
SCHEMBL315491	1.00	12/20
SCHEMBL315516	0.87	12/20
SCHEMBL315481	0.60	11/20
SCHEMBL159941	0.59	11/20
SCHEMBL314813	0.86	10/20
SCHEMBL315941	0.69	10/20
SCHEMBL316614	0.62	10/20
SCHEMBL317130	0.59	10/20
SCHEMBL315140	1.00	9/20
SCHEMBL315109	0.93	9/20
SCHEMBL315440	0.92	9/20
SCHEMBL316248	0.85	9/20

Clinical trials — most relevant to MMP12 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Estimation of MMP-8 Levels in GCF and Serum and Its Correlation With Wound Healing and Clinical Outcomes After Coronally Advanced Flap and Subepithelial Connective Tissue Graft for Root Coverage in Recession Defects: A CLINICO-BIOCHEMICAL STUDY	PHASE4	SUSPENDED
Doxycycline In Lymphangioleiomyomatosis (LAM)	PHASE4	COMPLETED
Magnetic Resonance Imaging of Aortic Aneurysm Instability	PHASE2/PHASE3	COMPLETED
Sputum Matrix Metalloproteinases (MMP) mRNA and Montelukast	PHASE2	COMPLETED
Adjunctive Doxycycline for Central Nervous System Tuberculosis	PHASE2	RECRUITING
Tetracycline (Doxycycline) and Post Myocardial Infarction Remodeling	PHASE2	COMPLETED
IRon Nanoparticle Enhanced MRI in the Assessment of Myocardial infarctioN	PHASE2	COMPLETED
The Role of Matrix Metalloproteinases (MMPs) in Orthodontic Tooth Movement	PHASE1	COMPLETED
A Phase I Study of Oral COL-3 (NSC-683551), a Matrix Metalloproteinase Inhibitor, in Patients With Refractory Metastatic Cancer	PHASE1	COMPLETED
The Study of Quadruple Therapy Quercetin, Zinc, Metformin, and EGCG as Adjuvant Therapy for Early, Metastatic Breast Cancer and Triple-negative Breast Cancer, a Novel Mechanism	EARLY_PHASE1	UNKNOWN
Correlation Between Serum Markers of Unstable Plaque and Virtual Histology of Unstable Plaque Visualized by IVUS	nan	COMPLETED
Cancer Fusion Hybrids and Desmoplasia	nan	UNKNOWN
The Impact of Pregnancy and Pregnancy-associated Hypertension on Human Uterine Myometrial Artery Reactivity	nan	WITHDRAWN
Role of A Disintegrin and Metalloproteinase (ADAM) in Epithelial Dysfunction	nan	COMPLETED
Re-evaluation of Some Old Rheumatoid Arthritis Therapy: A Randomized Controlled Trial	nan	COMPLETED
Mechanisms Underlying SGLT2i Kidney Effect in DKD Progression	nan	NOT_YET_RECRUITING
Influence of Statins in Artery Aneurysms	nan	UNKNOWN
Effect of Periodontal Therapy on Biomarkers in Periodontitis	nan	COMPLETED
Biobehavioral-Cytokine Interactions in Ovarian Cancer	nan	COMPLETED
Evaluation of Different Serum Cartilage Biomarkers in the Acute Response to Walking and Cycling in Healthy Male Subjects	nan	AVAILABLE
Evaluation of Salivary Biomarker Levels in Individuals With Different Periodontal Conditions	nan	COMPLETED
Characterization of Pulp Inflammation: an Observational Study Using Biological Samples Collected During Routine Dental Care	nan	NOT_YET_RECRUITING
Pathology, Venous Disease, and Clinical Correlations	nan	UNKNOWN
Matrix Metalloproteinases 7 and 9 in Rheumatoid Arthritis Patients With Interstitial Lung Disease	nan	NOT_YET_RECRUITING
Salivary Markers in Periodontal Disorders	nan	COMPLETED
Peri-implantitis and MMP-8	nan	COMPLETED
Evaluation of the Effectiveness of Physical Exercise on Aerobic Capacity in Patients With Cardiovascular Disease	nan	RECRUITING
Plasma and Scarring of Diabetic Ulcers	nan	COMPLETED
Characterizing the Inflammation Around Dental Implants: Bacterial Infection, Hypersensitivity or Both?	nan	RECRUITING
Macrophage Activation Markers in COVID-19 Patients	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a MMP12 binder may also engage these)

Protein	Name	Similarity
P57748	—	1.000	P57748 →
P79227	—	0.999	P79227 →
Q10835	—	0.999	Q10835 →
MMP1	Interstitial collagenase	0.998	landscape →
P07152	—	0.998	P07152 →
P34960	—	0.998	P34960 →
Q63341	—	0.998	Q63341 →
O70138	—	0.998	O70138 →
MMP20	Matrix metalloproteinase-20	0.997	landscape →
MMP8	Neutrophil collagenase	0.997	landscape →
O55123	—	0.997	O55123 →
O18767	—	0.997	O18767 →
MMP3	Stromelysin-1	0.996	landscape →
Q9EPL5	—	0.996	Q9EPL5 →
O88766	—	0.996	O88766 →
Q9GKE1	—	0.995	Q9GKE1 →
O62806	—	0.994	O62806 →
P28863	—	0.994	P28863 →
P21692	—	0.994	P21692 →
MMP10	Stromelysin-2	0.994	landscape →
O13065	—	0.994	O13065 →
Q6Y4Q5	—	0.994	Q6Y4Q5 →
P53690	—	0.994	P53690 →
O77656	—	0.993	O77656 →
P79287	—	0.993	P79287 →
P28862	—	0.993	P28862 →
Q28397	—	0.993	Q28397 →
P13943	—	0.993	P13943 →
P03957	—	0.993	P03957 →
Q10739	—	0.992	Q10739 →