Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 2/20 | 0.56 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.56 |
| ▸ | ABL1 | P00519 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | GRM5 | P41594 | 4/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | BRAF | P15056 | 1/20 | 0.44 |
| ▸ | CD38 | P28907 | 1/20 | 0.44 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.43 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 2/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | TEK | Q02763 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13765855 | 0.83 | KIT (0.56) | KITDDR1ABL1GAAGRM5 | |
| SCHEMBL10207523 | 0.79 | ABL1 (0.60) | KITDDR1ABL1GAAGRM5 | |
| SCHEMBL10207522 | 0.78 | ABL1 (0.61) | KITDDR1ABL1GAAPDGFRB | |
| SCHEMBL10207521 | 0.78 | ABL1 (0.79) | KITDDR1ABL1CSF1R | |
| SCHEMBL10207499 | 0.77 | ABL1 (0.51) | KITDDR1ABL1GAAGRM5 | |
| SCHEMBL20687013 | 0.77 | ABL1 (0.59) | KITDDR1ABL1GAAGRM5 | |
| SCHEMBL25136076 | 0.73 | ABL1 (0.65) | ABL1BRAFCD38CSF1RLMNA | |
| SCHEMBL30363890 | 0.73 | ABL1 (0.65) | ABL1BRAFCD38CSF1RLMNA | |
| SCHEMBL25135525 | 0.73 | ABL1 (0.71) | ABL1GAAROCK2MAPK13 | |
| SCHEMBL12851843 | 0.73 | KIT (0.59) | KITDDR1ABL1KDRDDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8278307-B2 | Monocyclic Heteroaryl compounds | ARIAD PHARMACEUTICALS, INC. (US) | 2012-10-02 | — | — | US | disclosed |
| US-20090149471-A1 | Monocyclic Heterocyclic Compounds | ARIAD PHARMACEUTICALS, INC. | 2009-06-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090149471-A1 | Monocyclic Heterocyclic Compounds | CYP11B2, CYP3A5, CYP1A2 | KIT 813/4885DDR1 4773/4885ABL1 357/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.