Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XIAP | P98170 | 19/20 | 0.58 |
| ▸ | BIRC2 | Q13490 | 8/20 | 0.58 |
| ▸ | BIRC3 | Q13489 | 7/20 | 0.58 |
| ▸ | BIRC8 | Q96P09 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15494083 | 1.00 | XIAP (0.58) | XIAPBIRC2BIRC3BIRC8MEN1 | |
| SCHEMBL9609060 | 0.92 | XIAP (0.67) | XIAPBIRC2BIRC3MEN1HTT | |
| SCHEMBL3726112 | 0.92 | XIAP (0.67) | XIAPBIRC2BIRC3MEN1HTT | |
| SCHEMBL27274363 | 0.87 | XIAP (0.50) | XIAPBIRC2BIRC3BIRC8 | |
| SCHEMBL12851912 | 0.84 | XIAP (0.70) | XIAPBIRC2BIRC3BIRC8 | |
| SCHEMBL9973499 | 0.84 | XIAP (0.70) | XIAPBIRC2BIRC3BIRC8 | |
| SCHEMBL19107325 | 0.83 | XIAP (0.54) | XIAPBIRC2BIRC3MEN1HTT | |
| SCHEMBL17211521 | 0.83 | XIAP (0.54) | XIAPBIRC2BIRC3MEN1HTT | |
| SCHEMBL15759005 | 0.83 | XIAP (0.54) | XIAPBIRC2BIRC3MEN1HTT | |
| SCHEMBL18651788 | 0.83 | XIAP (0.54) | XIAPBIRC2BIRC3MEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8664212-B2 | Diazo bicyclic Smac mimetics and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2014-03-04 | — | — | US | disclosed |
| US-20120309961-A1 | DIAZO BICYCLIC SMAC MIMETICS AND THE USES THEREOF | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-12-06 | — | — | US | disclosed |
| US-8278293-B2 | Diazo bicyclic Smac mimetics and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-10-02 | — | — | US | disclosed |
| US-20100273812-A1 | DIAZO BICYCLIC SMAC MIMETICS AND THE USES THEREOF | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2010-10-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100273812-A1 | DIAZO BICYCLIC SMAC MIMETICS AND THE USES THEREOF | BID, BAD, AIFM1 | XIAP 25/4885BIRC2 7/4885BIRC3 6/4885 |
| US-20120309961-A1 | DIAZO BICYCLIC SMAC MIMETICS AND THE USES THEREOF | BID, BAD, AIFM1 | XIAP 25/4885BIRC2 7/4885BIRC3 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.