AIFM1

Apoptosis-inducing factor 1, mitochondrial · O95831 · AIFM1 on Sugi Atlas →

0 patent compounds predicted against AIFM1, 0 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours

Clinical trials — most relevant to AIFM1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Clinical Study Evaluating the Anticancer Effect of Pentoxiphylline in Patients With Metastatic Colorectal Cancer PHASE4UNKNOWN
Impact if Desflurane Preconditioning on the Content of the Phospho-GSK-3b in the Rat's Neurons in the Model of I/R PHASE4WITHDRAWN
Cardioprotective Effects of Melatonin in Patients With Cardiomyopathy PHASE3RECRUITING
Sunphenon Epigallocatechin-Gallate (EGCg) in Duchenne Muscular Dystrophy PHASE2/PHASE3COMPLETED
Decitabine and Venetoclax Treatment as Maintenance Therapy in Patients Post Allograft Stem Cell Transplant PHASE1/PHASE2RECRUITING
ONC201 in Recurrent/Refractory Metastatic Breast Cancer and Advanced Endometrial Carcinoma PHASE2COMPLETED
Clinical Effects of Alpha-Lipoic Acid in Advanced NSCLC PHASE2NOT_YET_RECRUITING
Efficacy and Tolerability of Tauroursodeoxycholic Acid in Amyotrophic Lateral Sclerosis PHASE2COMPLETED
Influence of Morphine or Ketamine or Saline Applied During In-hospital Cardiopulmonary Resuscitation on Early Survival PHASE1UNKNOWN
A Phase I Study Of Thymoglobulin In Patients With Relapsed Or Refractory Multiple Myeloma PHASE1COMPLETED
A Phase I, Open-Labeled, Single-Arm, Dose Escalation, Clinical and Pharmacology Study of Dichloroacetate (DCA) in Patients With Recurrent and/or Metastatic Solid Tumours PHASE1COMPLETED
Remote Ischaemic Conditioning in Endovascular Recanalization for Proximal Anterior Circulation Occlusion Study PHASE1UNKNOWN
In Vivo Lithium Treatment Effects on Gene Expression Levels in Lymphoblastoid Cell Lines From Human Healthy Subjects PHASE1COMPLETED
Effectiveness of Light for Enhancement of Cognition by Transcranial Repeated Application (ELECTRA) EARLY_PHASE1COMPLETED
Apoptosis Markers in Aggressive Periodontitis nanCOMPLETED
Skeletal Muscle Apoptosis and Physical Performance; Oxidative RNA/DNA Damage and Repair in Aged Human Muscle nanCOMPLETED
Impact of CASP3 Gene in Chemoresistance nanNOT_YET_RECRUITING
Myocardial Affectation in Patients With Fabry Disease Without Phenotypic Manifestation. Diagnostic Value of Biomarkers nanUNKNOWN
Environmental Pollutants in COPD and Lung Cancer nanRECRUITING
Ccf mtDNA as a Neurodegenerative Biomarker nanUNKNOWN
Relationship Between Mitochondrial Dysfunction and Fatique in Cancer Patients Following External Beam Radiation Therapy nanCOMPLETED
Cerebrospinal Fluid Mitochondrial Biomarkers in Ischemic Stroke and Alzheimer Disease nanRECRUITING
Reactive Oxygen Species Following Aortic Valve Replacement nanCOMPLETED
Role of Sorcin and Annexin A3 in Breast Cancer Patients nanUNKNOWN
The Crosstalk Between the Epigenome and Mitochondria in SCI nanNOT_YET_RECRUITING
Cardiac Mitochondrial Function in Explanted Human Hearts nanUNKNOWN
Circulating Markers for Ischemic Heart Disease nanRECRUITING
Drug Repurposing for Mitochondrial Disorders Using iPSCs Derived Neural Cells nanRECRUITING
Mitigating Mitochondrial RNA Release During Aging to Control Inflammation and Senescence nanNOT_YET_RECRUITING
Transgenerational Metabolic-Immune Biomarkers of Neurological and Neurodevelopmental Disorders nanRECRUITING

Related proteins — ESM-2 sequence neighbours (a AIFM1 binder may also engage these)

ProteinNameSimilarity
Q9JM53 1.000 Q9JM53 →
Q9Z0X1 1.000 Q9Z0X1 →
Q9LK94 0.987 Q9LK94 →
TXNRD1 Thioredoxin reductase 1, cytoplasmic 0.987 landscape →
Q9VQ79 0.986 Q9VQ79 →
B2KWH9 0.985 B2KWH9 →
Q84PW3 0.985 Q84PW3 →
N4WYI1 0.985 N4WYI1 →
P82861 0.984 P82861 →
P36101 0.984 P36101 →
Q9P3K9 0.984 Q9P3K9 →
Q8S3R2 0.984 Q8S3R2 →
Q17745 0.983 Q17745 →
P91938 0.983 P91938 →
Q6DW73 0.983 Q6DW73 →
O13861 0.983 O13861 →
W7NDP3 0.983 W7NDP3 →
P12063 0.983 P12063 →
Q8VZ10 0.983 Q8VZ10 →
Q6DW75 0.983 Q6DW75 →
Q9U641 0.982 Q9U641 →
O23461 0.982 O23461 →
Q75AW4 0.982 Q75AW4 →
Q2UMY7 0.982 Q2UMY7 →
P16638 0.982 P16638 →
P39867 0.982 P39867 →
Q5BH52 0.982 Q5BH52 →
A8N2M6 0.982 A8N2M6 →
P11832 0.982 P11832 →
Q05531 0.982 Q05531 →