Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 4/20 | 0.61 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.51 |
| ▸ | CES2 | O00748 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28022193 | 0.98 | CES1 (0.64) | CES1PLA2G2CCES2TSHRHSD17B10 | |
| SCHEMBL28006923 | 0.98 | CES1 (0.64) | CES1PLA2G2CCES2TSHRHSD17B10 | |
| SCHEMBL28022170 | 0.98 | CES1 (0.64) | CES1PLA2G2CCES2TSHRHSD17B10 | |
| SCHEMBL19043522 | 0.98 | CES1 (0.64) | CES1PLA2G2CCES2TSHRHSD17B10 | |
| SCHEMBL128963 | 0.98 | CES1 (0.64) | CES1PLA2G2CCES2TSHRHSD17B10 | |
| SCHEMBL127742 | 0.92 | CES1 (0.52) | CES1PLA2G2CCES2TSHRHSD17B10 | |
| Fluoride SCHEMBL27418704 | 0.90 | CES1 (0.50) | CES1PLA2G2CCES2TSHRHSD17B10 | |
| SCHEMBL28349199 | 0.86 | CES1 (0.53) | CES1PLA2G2CCES2FAAH | |
| SCHEMBL28346432 | 0.86 | CES1 (0.49) | CES1PLA2G2CMAPTFAAHALDH1A1 | |
| SCHEMBL15823328 | 0.84 | CES1 (0.46) | CES1PLA2G2CCES2TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3653625-A1 | FUSED RING DERIVATIVE HAVING MGAT-2 INHIBITORY ACTIVITY | Shionogi & Co., Ltd (JP) | 2020-05-20 | — | — | EP | disclosed |
| CN-104114546-A | AMIDE COMPOUND AND USE THEREOF FOR PEST CONTROL | SUMITOMO CHEMICAL CO | 2014-10-22 | — | — | CN | disclosed |
| CN-103443089-A | Diene amides and their use against arthropods | SUMITOMO CHEMICAL CO | 2013-12-11 | — | — | CN | disclosed |
| US-8450319-B2 | Pyrrolopyridazinone compound | UBE INDUSTRIES, LTD. (JP) | 2013-05-28 | — | — | US | disclosed |
| EP-1982986-B1 | PYRROLOPYRIDAZINONE COMPOUND AS PDE4 INHIBITOR | UBE INDUSTRIES (JP) | 2012-03-07 | — | — | EP | disclosed |
| US-20090036453-A1 | Pyrrolopyridazinone Compound | UBE INDUSTRIES, LTD. (JP) | 2009-02-05 | — | — | US | disclosed |
| EP-1982986-A1 | PYRROLOPYRIDAZINONE COMPOUND | Ube Industries, Ltd. (JP) | 2008-10-22 | — | — | EP | disclosed |
| EP-0200657-B1 | PROCESS FOR THE PREPARATION OF TRIFLUOROETHOXY- OR TRIFLUOROETHYLTHIOBENZENES | RHONE-POULENC CHIMIE (FR) | 1988-11-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090036453-A1 | Pyrrolopyridazinone Compound | CBR3, CBR1, CYC1 | CES1 336/4885PLA2G2C 2106/4885CES2 190/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.