Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 19/20 | 1.00 |
| ▸ | MAPK11 | Q15759 | 5/20 | 0.62 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.62 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.44 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.44 |
| ▸ | GCGR | P47871 | 1/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.43 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.43 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.43 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Rwj-67657 SCHEMBL162010 | 1.00 | MAPK14 (1.00) | MAPK14MAPK11MAP4K4MAPK13MAPK12 | |
| Rwj-67657 SCHEMBL5815060 | 0.99 | MAPK14 (0.98) | MAPK14MAPK11MAP4K4MAPK13MAPK12 | |
| SCHEMBL5999009 | 0.95 | MAPK14 (0.91) | MAPK14MAPK11MAP4K4MAPK13MAPK12 | |
| SCHEMBL7145536 | 0.94 | MAPK14 (0.89) | MAPK14MAPK11MAP4K4MAPK13MAPK12 | |
| SCHEMBL5998654 | 0.93 | MAPK14 (0.87) | MAPK14MAPK11MAP4K4MAPK13MAPK12 | |
| SCHEMBL5820266 | 0.92 | MAPK14 (0.85) | MAPK14MAPK11MAP4K4MAPK13MAPK12 | |
| SCHEMBL13035057 | 0.90 | MAPK14 (0.82) | MAPK14MAPK11MAP4K4MAPK13MAPK12 | |
| SCHEMBL7141213 | 0.90 | MAPK14 (0.82) | MAPK14MAPK11MAP4K4MAPK13MAPK12 | |
| SCHEMBL1127681 | 0.90 | MAPK14 (0.81) | MAPK14MAPK11MAP4K4MAPK13MAPK12 | |
| SCHEMBL5997587 | 0.89 | MAPK14 (0.80) | MAPK14MAPK11MAP4K4MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1364212-B1 | THREE HYBRID ASSAY SYSTEM | GPC BIOTECH AG (DE) | 2011-02-02 | — | — | EP | disclosed |
| EP-1975620-A2 | Three hybrid assay system | GPC Biotech AG (DE) | 2008-10-01 | — | — | EP | disclosed |