Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 19/20 | 0.80 |
| ▸ | MAPK11 | Q15759 | 9/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 8/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 8/20 | 0.41 |
| ▸ | GCGR | P47871 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5998654 | 0.93 | MAPK14 (0.87) | MAPK14MAPK11MAP4K4MAPK13MAPK12 | |
| SCHEMBL5999009 | 0.90 | MAPK14 (0.91) | MAPK14MAPK11MAP4K4MAPK13MAPK12 | |
| SCHEMBL1127681 | 0.90 | MAPK14 (0.81) | MAPK14MAPK11MAP4K4MAPK13MAPK12 | |
| SCHEMBL7145536 | 0.89 | MAPK14 (0.89) | MAPK14MAPK11MAP4K4MAPK13MAPK12 | |
| SCHEMBL13035057 | 0.89 | MAPK14 (0.82) | MAPK14MAPK11MAP4K4MAPK13MAPK12 | |
| SCHEMBL7141213 | 0.89 | MAPK14 (0.82) | MAPK14MAPK11MAP4K4MAPK13MAPK12 | |
| Rwj-67657 SCHEMBL162010 | 0.89 | MAPK14 (1.00) | MAPK14MAPK11MAP4K4MAPK13MAPK12 | |
| SCHEMBL12856400 | 0.89 | MAPK14 (1.00) | MAPK14MAPK11MAP4K4MAPK13MAPK12 | |
| SCHEMBL7136973 | 0.88 | MAPK14 (0.78) | MAPK14MAPK11MAP4K4RIPK3MAPK13 | |
| SCHEMBL1127710 | 0.88 | MAPK14 (0.78) | MAPK14MAPK11MAP4K4MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028954-B1 | SUBSTITUTED IMIDAZOLES USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | ORTHO MCNEIL PHARM INC (US) | 2003-07-02 | — | — | EP | claimed |
| EP-1028954-A1 | SUBSTITUTED IMIDAZOLES USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | Ortho-McNeil Pharmaceutical, Inc. (US) | 2000-08-23 | — | — | EP | claimed |
| US-5965583-A | ANTIINFLAMMATORY AGENTS IN THE TREATMENT OF DISEASES ASSOCIATED WITH OVERPRODUCTION OF INFLAMMATORY CYTOKINES | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 1999-10-12 | — | — | US | claimed |
| WO-1998047892-A1 | SUBSTITUTED IMIDAZOLES USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | ORTHO-MCNEIL CORPORATION, INC. (US) | 1998-10-29 | — | — | WO | claimed |
| US-20060241150-A1 | P38 kinase inhibitor compositions and methods of using the same | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2006-10-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060241150-A1 | P38 kinase inhibitor compositions and methods of using the same | MAPK7, MAPK1, MAP3K7 | MAPK14 19/4885MAPK11 54/4885MAP4K4 66/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.