Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEK | Q02763 | 2/20 | 0.62 |
| ▸ | EGFR | P00533 | 3/20 | 0.55 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.55 |
| ▸ | ERBB4 | Q15303 | 3/20 | 0.55 |
| ▸ | IGF1R | P08069 | 2/20 | 0.55 |
| ▸ | ERBB3 | P21860 | 2/20 | 0.55 |
| ▸ | EIF2AK3 | Q9NZJ5 | 6/20 | 0.54 |
| ▸ | PLK4 | O00444 | 1/20 | 0.51 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.51 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | PAK4 | O96013 | 1/20 | 0.51 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.51 |
| ▸ | INSR | P06213 | 1/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
| ▸ | FYN | P06241 | 1/20 | 0.51 |
| ▸ | CSF1R | P07333 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6458902 | 1.00 | TEK (0.62) | TEKEGFRERBB2ERBB4IGF1R | |
| SCHEMBL6460446 | 0.94 | TEK (0.62) | TEKEGFRERBB2ERBB4IGF1R | |
| SCHEMBL6460184 | 0.92 | TEK (0.67) | TEKEGFRERBB2ERBB4IGF1R | |
| SCHEMBL6463702 | 0.92 | TEK (0.62) | TEKEGFRERBB2ERBB4IGF1R | |
| SCHEMBL6460329 | 0.91 | TEK (0.64) | TEKEGFRERBB2ERBB4IGF1R | |
| SCHEMBL6459192 | 0.91 | TEK (0.59) | TEKEGFRERBB2ERBB4IGF1R | |
| SCHEMBL6459268 | 0.91 | TEK (0.65) | TEKEGFRERBB2ERBB4IGF1R | |
| SCHEMBL2071744 | 0.90 | RIPK2 (0.51) | EGFRIGF1REIF2AK3ABL1NTRK1 | |
| SCHEMBL6461797 | 0.90 | TEK (0.64) | TEKEGFRERBB2ERBB4IGF1R | |
| SCHEMBL30527006 | 0.90 | TEK (0.64) | TEKEGFRERBB2ERBB4IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1364212-B1 | THREE HYBRID ASSAY SYSTEM | GPC BIOTECH AG (DE) | 2011-02-02 | — | — | EP | disclosed |
| EP-1975620-A2 | Three hybrid assay system | GPC Biotech AG (DE) | 2008-10-01 | — | — | EP | disclosed |