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Sugi Predict / Compounds / SCHEMBL1286040

SCHEMBL1286040

SCHEMBL1286040

COC(=O)[C@@H]1C2C=CC(C2)[C@@H]1C(=O)O

nearest known ligand 0.56

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ POLB P06746 3/20 0.56
▸ ALDH1A1 P00352 2/20 0.56
▸ SMN1; SMN2 Q16637 1/20 0.56
▸ KDM4E B2RXH2 1/20 0.51
▸ APEX1 P27695 1/20 0.50
▸ TDP1 Q9NUW8 1/20 0.50
▸ LMNA P02545 1/20 0.48
▸ PPM1B O75688 1/20 0.47
▸ PTPN1 P18031 1/20 0.47
▸ PPP1CC P36873 1/20 0.47
▸ MEN1 O00255 3/20 0.47
▸ KMT2A Q03164 3/20 0.47
▸ HTT P42858 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL390785 1.00 POLB (0.56) POLBALDH1A1SMN1; SMN2KDM4EAPEX1
SCHEMBL960068 1.00 POLB (0.56) POLBALDH1A1SMN1; SMN2KDM4EAPEX1
SCHEMBL3344598 1.00 POLB (0.56) POLBALDH1A1SMN1; SMN2KDM4EAPEX1
SCHEMBL12268155 1.00 POLB (0.56) POLBALDH1A1SMN1; SMN2KDM4EAPEX1
SCHEMBL392898 1.00 POLB (0.56) POLBALDH1A1SMN1; SMN2KDM4EAPEX1
SCHEMBL392940 1.00 POLB (0.56) POLBALDH1A1SMN1; SMN2KDM4EAPEX1
SCHEMBL15382009 1.00 POLB (0.56) POLBALDH1A1SMN1; SMN2KDM4EAPEX1
SCHEMBL390569 1.00 POLB (0.56) POLBALDH1A1SMN1; SMN2KDM4EAPEX1
SCHEMBL12268152 1.00 POLB (0.56) POLBALDH1A1SMN1; SMN2KDM4EAPEX1
SCHEMBL6737297 1.00 POLB (0.56) POLBALDH1A1SMN1; SMN2KDM4EAPEX1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4661890-A1 PTP1B/TC-PTP DUAL INHIBITORS AND PROTEIN DEGRADERS Purdue Research Foundation (US) 2025-12-17 — — EP claimed
WO-2024167565-A1 PTP1B/TC-PTP DUAL INHIBITORS AND PROTEIN DEGRADERS PURDUE RESEARCH FOUNDATION (US) 2024-08-15 — — WO claimed
US-10072043-B2 Inhibitors of protein tyrosine phosphatases INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) 2018-09-11 — — US claimed
US-20160176922-A1 INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES Indiana University Research and Technology Corpora tion (US) 2016-06-23 — — US claimed
US-9217012-B2 Inhibitors of protein tyrosine phosphatases INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) 2015-12-22 — — US claimed
US-20120088720-A1 INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATI (US) 2012-04-12 — — US claimed
WO-2010118241-A2 INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATION (US) 2010-10-14 — — WO claimed
US-6348296-B1 COPOLYMER CONSISTING OF 2,3-DI-TERT-BUTYL-5-NORBORNENE-2,3-DICARBOXYLATE, ANOTHER NORBORNENE MONOMER, AND MALEIC ANHYDRIDE HYUNDAI ELECTRONICS INDUSTRIES CO., LTD. (KR) 2002-02-19 — — US claimed
US-20010053834-A1 Semiconductor device using polymer-containing photoresist, and process for manufacturing the same JUNG MIN HO (KR) 2001-12-20 — — US claimed
EP-4661890-A1 PTP1B/TC-PTP DUAL INHIBITORS AND PROTEIN DEGRADERS Purdue Research Foundation (US) 2025-12-17 — — EP disclosed
WO-2024167565-A1 PTP1B/TC-PTP DUAL INHIBITORS AND PROTEIN DEGRADERS PURDUE RESEARCH FOUNDATION (US) 2024-08-15 — — WO disclosed
US-10072043-B2 Inhibitors of protein tyrosine phosphatases INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) 2018-09-11 — — US disclosed
US-20160176922-A1 INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES Indiana University Research and Technology Corpora tion (US) 2016-06-23 — — US disclosed
US-9217012-B2 Inhibitors of protein tyrosine phosphatases INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) 2015-12-22 — — US disclosed
US-6177464-B1 BACTERICIDES SEPRACOR, INC. 2001-01-23 — — US disclosed
EP-0912170-A1 HIV PROTEASE INHIBITORS USEFUL FOR THE TREATMENT OF AIDS Merck & Co., Inc. (US) 1999-05-06 — — EP disclosed
US-5811462-A (BICYCLO(2.2.1)HEPT-5'-EN-2'-YL-CARBONYL)AMINO-3-HYDROXY DERIVATIVES MERCK & CO., INC. (US) 1998-09-22 — — US disclosed
US-5801274-A N- mercaptoacyl(amino acid or peptide)! compounds and S-lipophilic aliphatic carbonyl derivatives thereof as antihypertensives INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) 1998-09-01 — — US disclosed
WO-1997040825-A1 HIV PROTEASE INHIBITORS USEFUL FOR THE TREATMENT OF AIDS MERCK & CO., INC. (US) 1997-11-06 — — WO disclosed
US-5591891-A PEPTIDASE INHIBITORS INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) 1997-01-07 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10072043-B2 Inhibitors of protein tyrosine phosphatases PTPRCAP, PTPRF, PTPRS POLB 4097/4885ALDH1A1 3087/4885SMN1; SMN2 4271/4885
US-20160176922-A1 INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES PTPRCAP, PTPRF, PTPRS POLB 4097/4885ALDH1A1 3087/4885SMN1; SMN2 4271/4885
US-20120088720-A1 INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES PTPRCAP, PTPRF, PTPRS POLB 4097/4885ALDH1A1 3087/4885SMN1; SMN2 4271/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.