Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | APEX1 | P27695 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | PPM1B | O75688 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | PPP1CC | P36873 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL390785 | 1.00 | POLB (0.56) | POLBALDH1A1SMN1; SMN2KDM4EAPEX1 | |
| SCHEMBL960068 | 1.00 | POLB (0.56) | POLBALDH1A1SMN1; SMN2KDM4EAPEX1 | |
| SCHEMBL12268155 | 1.00 | POLB (0.56) | POLBALDH1A1SMN1; SMN2KDM4EAPEX1 | |
| SCHEMBL392898 | 1.00 | POLB (0.56) | POLBALDH1A1SMN1; SMN2KDM4EAPEX1 | |
| SCHEMBL392940 | 1.00 | POLB (0.56) | POLBALDH1A1SMN1; SMN2KDM4EAPEX1 | |
| SCHEMBL1286040 | 1.00 | POLB (0.56) | POLBALDH1A1SMN1; SMN2KDM4EAPEX1 | |
| SCHEMBL15382009 | 1.00 | POLB (0.56) | POLBALDH1A1SMN1; SMN2KDM4EAPEX1 | |
| SCHEMBL390569 | 1.00 | POLB (0.56) | POLBALDH1A1SMN1; SMN2KDM4EAPEX1 | |
| SCHEMBL12268152 | 1.00 | POLB (0.56) | POLBALDH1A1SMN1; SMN2KDM4EAPEX1 | |
| SCHEMBL6737297 | 1.00 | POLB (0.56) | POLBALDH1A1SMN1; SMN2KDM4EAPEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023237512-A1 | COMBINATIONS OF RXFP1 MODULATORS AND SGLT2 INHIBITORS | ASTRAZENECA AB (SE) | 2023-12-14 | — | — | WO | disclosed |
| WO-2010042834-A1 | A METHOD OF INHIBITING HEPATITIS C VIRUS BY COMBINATION OF A 5,6-DIHYDRO-1H-PYRIDIN-2-ONE AND ONE OR MORE ADDITIONAL ANTIVIRAL COMPOUNDS | ANADYS PHARMACEUTICALS, INC. (US) | 2010-04-15 | — | — | WO | disclosed |
| EP-2129224-A1 | 5,6-DIHYDRO-1H-PYRIDIN-2-ONE COMPOUNDS | Anadys Pharmaceuticals, Inc. (US) | 2009-12-09 | — | — | EP | disclosed |
| WO-2008124450-A1 | 5,6-DIHYDRO-1H-PYRIDIN-2-ONE COMPOUNDS | ANADYS PHARMACEUTICALS, INC. (US) | 2008-10-16 | — | — | WO | disclosed |