Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 8/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.48 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.48 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.48 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.48 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1911473 | 0.88 | ALDH1A1 (0.55) | CNR2HSD17B10KDM5BKDM4EMEN1 | |
| SCHEMBL13086835 | 0.85 | CNR2 (0.55) | CNR2HSD17B10KDM5BKDM4EMEN1 | |
| SCHEMBL12864090 | 0.83 | CNR2 (0.62) | CNR2HSD17B10KDM4EMEN1ALDH1A1 | |
| SCHEMBL16773016 | 0.81 | CNR2 (0.69) | CNR2HSD17B10KDM4EMEN1ALDH1A1 | |
| SCHEMBL7294070 | 0.80 | CNR2 (0.62) | CNR2HSD17B10KDM4EMEN1ALDH1A1 | |
| SCHEMBL23266880 | 0.79 | ALDH1A1 (0.52) | CNR2HSD17B10KDM4EMEN1ALDH1A1 | |
| SCHEMBL18714256 | 0.79 | ALDH1A1 (0.52) | CNR2HSD17B10KDM4EMEN1ALDH1A1 | |
| SCHEMBL21202542 | 0.79 | ALDH1A1 (0.52) | CNR2HSD17B10KDM4EMEN1ALDH1A1 | |
| SCHEMBL21447902 | 0.79 | OGA (0.54) | CNR2HSD17B10KDM4EMEN1ALDH1A1 | |
| SCHEMBL2778332 | 0.79 | CNR2 (0.61) | CNR2HSD17B10KDM4EMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1896434-B1 | SUBSTITUTED HETEROARYL AMIDE MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NFkB ACTIVITY AND USE THEREOF | BRISTOL MYERS SQUIBB CO (US) | 2011-02-23 | — | — | EP | disclosed |
| US-7361654-B2 | Substituted heteroaryl amide modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof | BRISTOL-MYERS SQUIBB CO. (US) | 2008-04-22 | — | — | US | disclosed |