Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 16/20 | 0.61 |
| ▸ | PGR | P06401 | 4/20 | 0.61 |
| ▸ | ESR1 | P03372 | 2/20 | 0.61 |
| ▸ | AR | P10275 | 3/20 | 0.45 |
| ▸ | PREP | P48147 | 1/20 | 0.37 |
| ▸ | FAP | Q12884 | 1/20 | 0.37 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14196983 | 0.94 | NR3C1 (0.64) | NR3C1PGRESR1ARAOC3 | |
| SCHEMBL14197060 | 0.92 | NR3C1 (0.62) | NR3C1PGRESR1ARPREP | |
| SCHEMBL12864339 | 0.92 | NR3C1 (0.62) | NR3C1PGRESR1ARAOC3 | |
| SCHEMBL12864144 | 0.92 | NR3C1 (0.61) | NR3C1PGRESR1ARAOC3 | |
| SCHEMBL12864644 | 0.92 | NR3C1 (0.61) | NR3C1PGRESR1ARAOC3 | |
| SCHEMBL12864479 | 0.92 | NR3C1 (0.61) | NR3C1PGRESR1ARPREP | |
| SCHEMBL12864136 | 0.91 | NR3C1 (0.60) | NR3C1PGRESR1ARAOC3 | |
| SCHEMBL12863999 | 0.90 | NR3C1 (0.62) | NR3C1PGRESR1ARAOC3 | |
| SCHEMBL12864138 | 0.90 | NR3C1 (0.59) | NR3C1PGRESR1ARAOC3 | |
| SCHEMBL12864103 | 0.90 | NR3C1 (0.59) | NR3C1PGRESR1ARPREP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1896434-B1 | SUBSTITUTED HETEROARYL AMIDE MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NFkB ACTIVITY AND USE THEREOF | BRISTOL MYERS SQUIBB CO (US) | 2011-02-23 | — | — | EP | disclosed |
| US-7361654-B2 | Substituted heteroaryl amide modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof | BRISTOL-MYERS SQUIBB CO. (US) | 2008-04-22 | — | — | US | disclosed |