Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K4 | P45985 | 4/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.51 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 4/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.37 |
| ▸ | MGAM | O43451 | 3/20 | 0.37 |
| ▸ | SI | P14410 | 3/20 | 0.37 |
| ▸ | MGAM2 | Q2M2H8 | 3/20 | 0.37 |
| ▸ | TTK | P33981 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | KIT | P10721 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | FLT3 | P36888 | 2/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8404437 | 0.79 | MAPK1 (0.54) | MAP2K4MAPK1MAPKAPK2MAPK6GAA | |
| SCHEMBL1172394 | 0.76 | GAA (0.56) | MAP2K4MAPK1GAAPDPK1CHEK1 | |
| SCHEMBL23604563 | 0.76 | PDPK1 (0.52) | MAP2K4MAPK1GAAPDPK1CHEK1 | |
| SCHEMBL7737026 | 0.76 | GAA (0.47) | MAP2K4MAPK1MAPKAPK2MAPK6GAA | |
| SCHEMBL14631680 | 0.76 | MAPK1 (0.51) | MAP2K4MAPK1MAPKAPK2MAPK6GAA | |
| SCHEMBL31190844 | 0.76 | MAPK1 (0.51) | MAP2K4MAPK1MAPKAPK2MAPK6GAA | |
| SCHEMBL24455090 | 0.76 | MAPK1 (0.51) | MAP2K4MAPK1MAPKAPK2MAPK6GAA | |
| SCHEMBL23206119 | 0.76 | GAA (0.35) | MAP2K4MAPK1MAPKAPK2MAPK6GAA | |
| SCHEMBL569660 | 0.76 | GAA (0.61) | MAP2K4MAPK1MAPKAPK2MAPK6GAA | |
| SCHEMBL28445675 | 0.76 | MAPK1 (0.60) | MAP2K4MAPK1MAPKAPK2MAPK6GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110046108-A1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2011-02-24 | — | — | US | disclosed |
| US-20110046108-A1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2011-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110046108-A1 | PYRIMIDINE DERIVATIVES | EPHB4, EPHB1, EPHB3 | MAP2K4 737/4885MAPK1 739/4885MAPKAPK2 925/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.