Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 6/20 | 0.65 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.63 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.62 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.62 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.62 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.62 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.62 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.62 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.62 |
| ▸ | HTR2A | P28223 | 1/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.62 |
| ▸ | MAOA | P21397 | 5/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.55 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.55 |
| ▸ | SNCA | P37840 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13623693 | 1.00 | MAOB (0.65) | MAOBSIGMAR1SLC6A2ADRA2BADRA2C | |
| SCHEMBL19285766 | 0.91 | MAOB (0.69) | MAOBSIGMAR1SLC6A2ADRA2BADRA2C | |
| Dimetamfetamine SCHEMBL2110135 | 0.86 | SLC6A4 (0.67) | MAOBSIGMAR1SLC6A2ADRA2BADRA2C | |
| Dimetamfetamine SCHEMBL12203605 | 0.86 | SLC6A4 (0.67) | MAOBSIGMAR1SLC6A2ADRA2BADRA2C | |
| Dimetamfetamine SCHEMBL727641 | 0.86 | SLC6A4 (0.67) | MAOBSIGMAR1SLC6A2ADRA2BADRA2C | |
| Dimetamfetamine SCHEMBL28689942 | 0.84 | SLC6A4 (0.64) | MAOBSIGMAR1SLC6A2ADRA2BADRA2C | |
| Dimetamfetamine SCHEMBL30559567 | 0.84 | SLC6A4 (0.64) | MAOBSIGMAR1SLC6A2ADRA2BADRA2C | |
| Dimetamfetamine SCHEMBL11773332 | 0.84 | SLC6A4 (0.64) | MAOBSIGMAR1SLC6A2ADRA2BADRA2C | |
| Dimetamfetamine SCHEMBL5091391 | 0.84 | SLC6A4 (0.64) | MAOBSIGMAR1SLC6A2ADRA2BADRA2C | |
| Dimetamfetamine SCHEMBL5091346 | 0.84 | SLC6A4 (0.64) | MAOBSIGMAR1SLC6A2ADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7888363-B2 | 1-Cyclopentyl-3-methyl-2-(2-pyridyl)indole-5-amino/thio/carbonyl derivatives; hepatitis C virus infection; synergistic with another inhibitor of HCV polymerase or immunomodulatory agent such as interferons | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-02-15 | — | — | US | disclosed |
| US-20070142380-A1 | Viral Polymerase Inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-06-21 | — | — | US | disclosed |
| US-7223785-B2 | Viral polymerase inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-05-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070142380-A1 | Viral Polymerase Inhibitors | POLM, POLR2H, POLR2A | MAOB 323/4885SIGMAR1 929/4885SLC6A2 1397/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.