Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | PEPD | P12955 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1287061 | 1.00 | OPRK1 (0.40) | OPRK1ALDH1A1SMN1; SMN2PEPDTP53 | |
| SCHEMBL1287001 | 1.00 | OPRK1 (0.40) | OPRK1ALDH1A1SMN1; SMN2PEPDTP53 | |
| SCHEMBL1287053 | 0.91 | HSD17B10 (0.33) | OPRK1SMN1; SMN2HSD17B10 | |
| SCHEMBL1287057 | 0.91 | HSD17B10 (0.33) | OPRK1SMN1; SMN2HSD17B10 | |
| SCHEMBL1287054 | 0.91 | HSD17B10 (0.33) | OPRK1SMN1; SMN2HSD17B10 | |
| SCHEMBL1287065 | 0.85 | GAA (0.31) | GAAHSD17B10 | |
| SCHEMBL1287123 | 0.85 | GAA (0.31) | GAAHSD17B10 | |
| SCHEMBL1287122 | 0.85 | GAA (0.31) | GAAHSD17B10 | |
| SCHEMBL1287066 | 0.85 | GAA (0.31) | GAAHSD17B10 | |
| SCHEMBL1287064 | 0.85 | GAA (0.31) | GAAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012047156-A1 | ISOXAZOL-3(2H)-ONE ANALOGS AS PLASMINOGEN INHIBITORS AND THEIR USE IN THE TREATMENT OF FIBRINOLYSIS RELATED DISEASES | ASTRAZENECA AB (SE) | 2012-04-12 | — | — | WO | disclosed |