Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.94 |
| ▸ | MAOB | P27338 | 3/20 | 0.83 |
| ▸ | MAPT | P10636 | 5/20 | 0.80 |
| ▸ | LMNA | P02545 | 2/20 | 0.80 |
| ▸ | RAB9A | P51151 | 2/20 | 0.80 |
| ▸ | NPC1 | O15118 | 1/20 | 0.80 |
| ▸ | HTT | P42858 | 1/20 | 0.80 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.78 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.78 |
| ▸ | MEN1 | O00255 | 2/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.78 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.78 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.78 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.78 |
| ▸ | BCHE | P06276 | 4/20 | 0.76 |
| ▸ | ACHE | P22303 | 1/20 | 0.76 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.75 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.75 |
| ▸ | RELA | Q04206 | 1/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1180393 | 1.00 | ABCG2 (0.94) | ABCG2MAOBMAPTLMNARAB9A | |
| SCHEMBL9341818 | 0.91 | ABCG2 (0.89) | ABCG2MAOBMAPTLMNARAB9A | |
| SCHEMBL15631514 | 0.91 | ABCG2 (0.89) | ABCG2MAOBMAPTLMNARAB9A | |
| SCHEMBL8987069 | 0.91 | MAOB (1.00) | ABCG2MAOBMAPTLMNARAB9A | |
| SCHEMBL8987072 | 0.91 | MAOB (1.00) | ABCG2MAOBMAPTLMNARAB9A | |
| SCHEMBL28562761 | 0.90 | ABCG2 (0.86) | ABCG2MAOBMAPTLMNARAB9A | |
| SCHEMBL31298986 | 0.89 | MAOB (0.86) | ABCG2MAOBMAPTLMNARAB9A | |
| SCHEMBL21002197 | 0.89 | MAOB (0.86) | ABCG2MAOBMAPTLMNARAB9A | |
| SCHEMBL1321090 | 0.89 | ABCG2 (0.84) | ABCG2MAOBMAPTLMNARAB9A | |
| SCHEMBL1321091 | 0.89 | ABCG2 (0.84) | ABCG2MAOBMAPTLMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110046147-A1 | 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS FOR THE TREATMENT OF HORMONE-RELATED DISEASES | UNIVERSITAT DES SAARLANDES (DE) | 2011-02-24 | — | — | US | disclosed |
| US-20110046147-A1 | 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS FOR THE TREATMENT OF HORMONE-RELATED DISEASES | UNIVERSITAT DES SAARLANDES (DE) | 2011-02-24 | — | — | US | disclosed |
| WO-2009027346-A2 | 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS FOR THE TREATMENT OF HORMONE-DEPENDENT DISEASES | Universität des Saarlandes (DE) | 2009-03-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110046147-A1 | 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS FOR THE TREATMENT OF HORMONE-RELATED DISEASES | HSD17B1, HSD17B11, HSD17B2 | ABCG2 4425/4885MAOB 434/4885MAPT 2231/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.