Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12463067 | 0.77 | SMN1; SMN2 (0.48) | SMN1; SMN2P2RX7KMT2AMEN1CA2 | |
| SCHEMBL2112086 | 0.74 | SMN1; SMN2 (0.45) | SMN1; SMN2KMT2AMEN1CA2TNKS2 | |
| SCHEMBL2112084 | 0.74 | SMN1; SMN2 (0.45) | SMN1; SMN2KMT2AMEN1CA2TNKS2 | |
| SCHEMBL7358888 | 0.74 | SMN1; SMN2 (0.49) | SMN1; SMN2KMT2AMEN1CA2MAPT | |
| SCHEMBL2112085 | 0.74 | SMN1; SMN2 (0.45) | SMN1; SMN2KMT2AMEN1CA2TNKS2 | |
| SCHEMBL13798670 | 0.74 | SMN1; SMN2 (0.49) | SMN1; SMN2KMT2AMEN1CA2MAPT | |
| SCHEMBL13811563 | 0.74 | SMN1; SMN2 (0.45) | SMN1; SMN2KMT2AMEN1CA2TNKS2 | |
| SCHEMBL5521516 | 0.74 | SMN1; SMN2 (0.45) | SMN1; SMN2KMT2AMEN1CA2TNKS2 | |
| SCHEMBL9511228 | 0.74 | SMN1; SMN2 (0.45) | SMN1; SMN2KMT2AMEN1CA2TNKS2 | |
| SCHEMBL15669988 | 0.74 | SMN1; SMN2 (0.54) | SMN1; SMN2P2RX7KMT2AMEN1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7893283-B2 | Protected taxane chemical intermediates ; one step; using beta-lactam, oxazolidine or oxazoline | CHATHAM BIOTEC, LIMITED (CA) | 2011-02-22 | — | — | US | disclosed |