Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 14/20 | 0.64 |
| ▸ | PDE11A | Q9HCR9 | 2/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8402320 | 0.88 | BTK (0.83) | BTKPDE11AKITKDR | |
| SCHEMBL1163758 | 0.78 | BTK (1.00) | BTKPDE11ASRCKITKDR | |
| SCHEMBL8402292 | 0.77 | BTK (0.80) | BTKPDE11AKITPDGFRAKDR | |
| SCHEMBL8402304 | 0.72 | BTK (0.74) | BTKKITKDR | |
| SCHEMBL6115784 | 0.72 | BTK (0.81) | BTKPDE11ASRCKITKDR | |
| SCHEMBL6115895 | 0.71 | BTK (0.78) | BTKKITPDGFRAKDRMAPT | |
| SCHEMBL1163040 | 0.70 | BTK (0.65) | BTK | |
| SCHEMBL18800885 | 0.70 | BTK (0.48) | BTKPDE11ASRCKDR | |
| SCHEMBL8402297 | 0.70 | BTK (0.72) | BTKSRCKITKDRMAPT | |
| SCHEMBL6115716 | 0.70 | BTK (1.00) | BTKKITKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011019780-A1 | AZAINDAZOLES AS BTK KINASE MODULATORS AND USE THEREOF | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-02-17 | — | — | WO | disclosed |