Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 7/20 | 0.48 |
| ▸ | SRC | P12931 | 5/20 | 0.39 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.37 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 3/20 | 0.34 |
| ▸ | TEK | Q02763 | 3/20 | 0.34 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | PLG | P00747 | 1/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18800559 | 0.91 | BTK (0.58) | BTKSRCPDE11AMAPK8MAPK10 | |
| SCHEMBL18800558 | 0.90 | BTK (0.43) | BTKPDE11AMAPK10ALDH1A1 | |
| SCHEMBL18800468 | 0.84 | BTK (0.49) | BTKSRCPDE11AFGFR1ALDH1A1 | |
| SCHEMBL18800884 | 0.82 | BTK (0.42) | BTK | |
| SCHEMBL18800792 | 0.82 | BTK (0.47) | BTKFGFR1MAPK10 | |
| SCHEMBL18800891 | 0.81 | BTK (0.62) | BTKPLAUF2PLGPRSS1 | |
| SCHEMBL18800784 | 0.81 | BTK (0.46) | BTK | |
| SCHEMBL18800770 | 0.81 | BTK (0.57) | BTKKDRF2PLGPRSS1 | |
| SCHEMBL18800772 | 0.80 | ADORA1 (0.43) | BTKSRCPDE11ALCKKDR | |
| SCHEMBL18800886 | 0.79 | BTK (0.42) | BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2789615-B1 | Azaindazoles as Btk kinase modulators and use thereof | BRISTOL MYERS SQUIBB CO (US) | 2017-05-03 | — | — | EP | disclosed |