Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 9/20 | 0.38 |
| ▸ | ABL1 | P00519 | 2/20 | 0.35 |
| ▸ | BCR | P11274 | 2/20 | 0.35 |
| ▸ | DHFR | P00374 | 2/20 | 0.35 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.34 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.34 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | ATR | Q13535 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12875187 | 0.89 | KDR (0.40) | BTKATRKDR | |
| SCHEMBL6115612 | 0.80 | BTK (0.57) | BTKATRACHEMKNK1MKNK2 | |
| SCHEMBL12874717 | 0.77 | BTK (0.46) | BTKACHE | |
| SCHEMBL12874549 | 0.75 | PDPK1 (0.39) | BTK | |
| SCHEMBL6116478 | 0.73 | BTK (0.64) | BTKMKNK1MKNK2 | |
| SCHEMBL1163048 | 0.72 | BTK (0.53) | BTKFYNATRKDR | |
| SCHEMBL6116157 | 0.71 | NPC1 (0.53) | BTKATRKDR | |
| SCHEMBL6115982 | 0.70 | BTK (0.56) | BTKFYN | |
| SCHEMBL13329711 | 0.70 | SMN1; SMN2 (0.50) | FYNATRKDR | |
| SCHEMBL2231538 | 0.69 | DHFR (0.43) | DHFRFYNATRKDRMKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011019780-A1 | AZAINDAZOLES AS BTK KINASE MODULATORS AND USE THEREOF | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-02-17 | — | — | WO | disclosed |