Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 5/20 | 0.43 |
| ▸ | RAB9A | P51151 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.35 |
| ▸ | RELA | Q04206 | 2/20 | 0.35 |
| ▸ | JUN | P05412 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.35 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28950678 | 0.81 | NPC1 (0.36) | SMN1; SMN2NPC1RAB9AALDH1A1KMT2A | |
| SCHEMBL10184712 | 0.80 | KMT2A (0.53) | SMN1; SMN2NPC1RAB9AMAPTLMNA | |
| SCHEMBL8573566 | 0.77 | RAB9A (0.50) | SMN1; SMN2NPC1RAB9AMAPTLMNA | |
| SCHEMBL12868446 | 0.77 | RAB9A (0.46) | SMN1; SMN2NPC1RAB9AMAPTLMNA | |
| SCHEMBL1198771 | 0.76 | SMN1; SMN2 (0.41) | SMN1; SMN2NPC1RAB9AMAPTLMNA | |
| SCHEMBL23366843 | 0.76 | SMN1; SMN2 (0.39) | SMN1; SMN2NPC1RAB9AMAPTLMNA | |
| SCHEMBL1663553 | 0.74 | SMN1; SMN2 (0.50) | SMN1; SMN2NPC1RAB9AMAPTLMNA | |
| SCHEMBL1641560 | 0.74 | SMN1; SMN2 (0.54) | SMN1; SMN2NPC1RAB9AMAPTLMNA | |
| SCHEMBL1198000 | 0.73 | SMN1; SMN2 (0.36) | SMN1; SMN2NPC1RAB9ALMNAALDH1A1 | |
| SCHEMBL1198574 | 0.73 | SMN1; SMN2 (0.47) | SMN1; SMN2NPC1LMNAKMT2AGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104395301-B | Bicyclic thiophene base amide compound | 霍夫曼-拉罗奇有限公司 | 2017-07-28 | — | — | CN | disclosed |
| US-8461348-B2 | Heterocyclic derivative and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-06-11 | — | — | US | disclosed |
| US-20110028493-A1 | HETEROCYCLIC DERIVATIVE AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110028493-A1 | HETEROCYCLIC DERIVATIVE AND USE THEREOF | PDE3B, PDE5A, PDE2A | SMN1; SMN2 2057/4885NPC1 3877/4885RAB9A 2507/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.