Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 2/20 | 0.31 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.30 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9923108 | 0.79 | KMT2A (0.38) | CDK2KDM4EALDH1A1POLBRXFP1 | |
| SCHEMBL9923104 | 0.79 | CDK2 (0.31) | CDK2 | |
| SCHEMBL9923307 | 0.75 | CDK2 (0.34) | CDK2CSNK1A1CLK4KDM4EALDH1A1 | |
| SCHEMBL9923423 | 0.70 | MEN1 (0.36) | CDK2KDM4EALDH1A1LMNAPOLB | |
| SCHEMBL9920417 | 0.69 | — | — | |
| SCHEMBL9923278 | 0.68 | CDK2 (0.41) | CDK2CSNK1A1CLK4KDM4EALDH1A1 | |
| SCHEMBL9923348 | 0.68 | CDK2 (0.38) | CDK2CSNK1A1CLK4KDM4EALDH1A1 | |
| SCHEMBL1160390 | 0.68 | CDK2 (0.49) | CDK2KDM4EALDH1A1 | |
| SCHEMBL9923105 | 0.67 | PKM (0.34) | ALDH1A1 | |
| SCHEMBL12492445 | 0.65 | CDK2 (0.35) | CDK2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013033093-A1 | HETEROCYCLIC COMPOUNDS AS JANUS KINASE INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2013-03-07 | — | — | WO | disclosed |
| WO-2011014817-A1 | PYRROLO [1, 2-B] PYRIDAZINE DERIVATIVES AS JANUS KINASE INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2011-02-03 | — | — | WO | disclosed |