SCHEMBL1287699

SCHEMBL1287699

COc1ccc(F)cc1CCN[C@@H]1C[C@H]1c1ccccc1

nearest known ligand 0.78

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
KDM1A O60341 18/20 0.78
MAOA P21397 14/20 0.78
MAOB P27338 11/20 0.78

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL237944 0.88 KDM1A (1.00) KDM1AMAOAMAOB
SCHEMBL2755995 0.88 KDM1A (1.00) KDM1AMAOAMAOB
SCHEMBL237943 0.88 KDM1A (1.00) KDM1AMAOAMAOB
SCHEMBL1287444 0.80 KDM1A (0.77) KDM1AMAOAMAOB
SCHEMBL240308 0.78 KDM1A (1.00) KDM1AMAOAMAOB
SCHEMBL2755985 0.78 KDM1A (1.00) KDM1AMAOAMAOB
SCHEMBL240309 0.78 KDM1A (1.00) KDM1AMAOAMAOB
SCHEMBL6798638 0.75 HTR1A (0.55) KDM1AMAOAMAOB
SCHEMBL6798636 0.75 HTR1A (0.55) KDM1AMAOAMAOB
SCHEMBL238969 0.75 KDM1A (0.77) KDM1AMAOAMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2389362-A1 PHENYLCYCLOPROPYLAMINE DERIVATIVES AND THEIR MEDICAL USE Oryzon Genomics, S.A. (ES) 2011-11-30 EP claimed
US-20110252680-A1 Surface mounted frame arrangement ROSE DISPLAYS, LTD 2011-10-20 US claimed
WO-2010084160-A1 PHENYLCYCLOPROPYLAMINE DERIVATIVES AND THEIR MEDICAL USE ORYZON GENOMICS S.A. (ES) 2010-07-29 WO claimed
EP-3716963-A1 ENHANCING T-CELL FUNCTION AND TREATING A T-CELL DYSFUNCTIONAL DISORDER WITH A COMBINATION OF AN LSD INHIBITOR AND A PD1 BINDING ANTAGONIST Epiaxis Therapeutics Pty Ltd (AU) 2020-10-07 EP disclosed
EP-3185858-A1 COMPOSITIONS FOR MODULATING CANCER STEM CELLS AND USES THEREFOR University of Canberra (AU) 2017-07-05 EP disclosed
EP-3013424-A1 METHODS AND COMPOSITIONS FOR MODULATING CANCER STEM CELLS University of Canberra (AU) 2016-05-04 EP disclosed
WO-2016029262-A1 COMPOSITIONS FOR MODULATING CANCER STEM CELLS AND USES THEREFOR UNIVERSITY OF CANBERRA (AU) 2016-03-03 WO disclosed
WO-2014205511-A1 METHODS AND COMPOSITIONS FOR MODULATING CANCER STEM CELLS UNIVERSITY OF CANBERRA (AU) 2014-12-31 WO disclosed
WO-2012047852-A2 COMPOSITIONS AND METHODS FOR MODULATING IMMUNODEFICIENCY VIRUS TRANSCRIPTION THE J. DAVID GLADSTONE INSTITUTES (US) 2012-04-12 WO disclosed
EP-2389362-A1 PHENYLCYCLOPROPYLAMINE DERIVATIVES AND THEIR MEDICAL USE Oryzon Genomics, S.A. (ES) 2011-11-30 EP disclosed
US-20110252680-A1 Surface mounted frame arrangement ROSE DISPLAYS, LTD 2011-10-20 US disclosed
WO-2010084160-A1 PHENYLCYCLOPROPYLAMINE DERIVATIVES AND THEIR MEDICAL USE ORYZON GENOMICS S.A. (ES) 2010-07-29 WO disclosed