SCHEMBL12877321

SCHEMBL12877321

CN1CCc2c(c3cc(Cl)ccc3n2CC(C)(O)C(=O)OC2CCCC2)C1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 7/20 0.54
HDAC1 Q13547 6/20 0.54
BAZ2B Q9UIF8 5/20 0.46
MAOA P21397 1/20 0.41
MAOB P27338 1/20 0.41
PTGDR2 Q9Y5Y4 1/20 0.41
HTR6 P50406 6/20 0.41
HRH1 P35367 5/20 0.39
HDAC3 O15379 1/20 0.39
HDAC4 P56524 1/20 0.39
HDAC7 Q8WUI4 1/20 0.39
HDAC2 Q92769 1/20 0.39
HDAC10 Q969S8 1/20 0.39
HDAC11 Q96DB2 1/20 0.39
HDAC8 Q9BY41 1/20 0.39
HDAC9 Q9UKV0 1/20 0.39
HDAC5 Q9UQL6 1/20 0.39
NCOR2 Q9Y618 1/20 0.39
ADRA2A P08913 1/20 0.39
HTR2A P28223 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12819460 0.93 HDAC1 (0.45) HDAC6HDAC1BAZ2BPTGDR2HDAC3
SCHEMBL13534097 0.84 HDAC1 (0.55) HDAC6HDAC1BAZ2BMAOAMAOB
SCHEMBL3318006 0.83 BAZ2B (0.56) HDAC6HDAC1BAZ2BMAOAMAOB
SCHEMBL13293449 0.78 BAZ2B (0.49) HDAC6HDAC1BAZ2BPTGDR2
SCHEMBL6921947 0.77 HTR6 (0.37) PTGDR2HTR6
SCHEMBL2189765 0.77 HDAC1 (0.57) HDAC6HDAC1BAZ2BMAOAMAOB
SCHEMBL14963869 0.77 HDAC1 (0.54) HDAC6HDAC1BAZ2BMAOAMAOB
SCHEMBL12877307 0.76 HDAC6 (0.57) HDAC6HDAC1MAOAMAOBHTR6
SCHEMBL3721776 0.76 HDAC1 (0.53) HDAC6HDAC1BAZ2BMAOAMAOB
SCHEMBL13696088 0.76 HTR6 (0.54) HDAC6HDAC1HTR6HRH1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011014695-A1 NEW 2,3,4,5-TETRAHYDRO-1H-PYRIDO[4,3-B] INDOLES AND METHODS OF USE MEDIVATION TECHNOLOGIES, INC. (US) 2011-02-03 WO disclosed