Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 5/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3655329 | 0.94 | PDE4B (0.42) | PDE4BPDE4APDE4CPDE4DL3MBTL1 | |
| SCHEMBL3657862 | 0.92 | PDE4B (0.41) | PDE4BPDE4APDE4CPDE4DL3MBTL1 | |
| SCHEMBL1203396 | 0.90 | PDE4B (0.44) | PDE4BPDE4APDE4CPDE4DL3MBTL1 | |
| SCHEMBL1202823 | 0.89 | PDE4B (0.44) | PDE4BPDE4APDE4CPDE4DMAPT | |
| SCHEMBL1202825 | 0.89 | PDE4B (0.44) | PDE4BPDE4APDE4CPDE4DMAPT | |
| SCHEMBL13968071 | 0.87 | PDE4B (0.42) | PDE4BPDE4APDE4CPDE4DL3MBTL1 | |
| SCHEMBL3659424 | 0.85 | PDE4B (0.42) | PDE4BPDE4APDE4CPDE4DMAPT | |
| SCHEMBL8040388 | 0.83 | PDE4B (0.41) | PDE4BPDE4APDE4CPDE4DL3MBTL1 | |
| SCHEMBL15494222 | 0.82 | L3MBTL1 (0.42) | PDE4BPDE4APDE4CPDE4DL3MBTL1 | |
| SCHEMBL3659144 | 0.81 | L3MBTL1 (0.37) | PDE4BPDE4APDE4CPDE4DL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140187786-A1 | 1,3,4-TRISUBSTITUTED BENZENES | ENVIVO PHARMACEUTICALS, INC. (US) | 2014-07-03 | — | — | US | disclosed |
| US-20110040094-A1 | 1,3,4-TRISUBSTITUTED BENZENES | ENVIVO PHARMACEUTICALS, INC. (US) | 2011-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110040094-A1 | 1,3,4-TRISUBSTITUTED BENZENES | BACE1, BACE2, PSEN1 | PDE4B 2041/4885PDE4A 2117/4885PDE4C 3188/4885 |
| US-20140187786-A1 | 1,3,4-TRISUBSTITUTED BENZENES | BACE1, BACE2, PSEN1 | PDE4B 2041/4885PDE4A 2117/4885PDE4C 3188/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.