Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | SCN1A | P35498 | 1/20 | 0.39 |
| ▸ | SCN4A | P35499 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.39 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.39 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.39 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12880750 | 1.00 | TDP1 (0.44) | TDP1GAAHPGDMAPK1KCNH2 | |
| SCHEMBL9037246 | 0.79 | SIGMAR1 (0.40) | TDP1KCNH2ALDH1A1CACNA1FMAPT | |
| SCHEMBL13668214 | 0.77 | TDP1 (0.39) | TDP1GAAHPGDMAPK1AKR1B1 | |
| SCHEMBL13668212 | 0.77 | TDP1 (0.39) | TDP1GAAHPGDMAPK1AKR1B1 | |
| SCHEMBL242119 | 0.72 | GAA (0.40) | TDP1GAAHPGDMAPK1SLC6A9 | |
| SCHEMBL6235555 | 0.72 | CRBN (0.43) | TDP1GAAHPGDMAPK1KCNH2 | |
| SCHEMBL15229601 | 0.72 | TDP1 (0.42) | TDP1GAAHPGDMAPK1KCNH2 | |
| SCHEMBL940436 | 0.68 | GAA (0.44) | TDP1GAAHPGDMAPK1ALDH1A1 | |
| SCHEMBL5358079 | 0.68 | CRBN (0.49) | KCNH2ALDH1A1CACNA1FMAPTCYP2C9 | |
| SCHEMBL14117525 | 0.68 | CRBN (0.49) | KCNH2ALDH1A1CACNA1FMAPTCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130123618-A1 | Imaging Agents | EMORY UNIVERSITY (US) | 2013-05-16 | — | — | US | disclosed |
| US-20110033382-A1 | Imaging Agents | EMORY UNIVERSITY (US) | 2011-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110033382-A1 | Imaging Agents | FOLH1, FABP7, SLC1A2 | TDP1 3204/4885GAA 1929/4885HPGD 4636/4885 |
| US-20130123618-A1 | Imaging Agents | FOLH1, FABP7, SLC1A2 | TDP1 3204/4885GAA 1929/4885HPGD 4636/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.