Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2677321 | 0.98 | EPHX2 (0.64) | EPHX2ALDH1A1EPHX1SMN1; SMN2CXCR4 | |
| SCHEMBL16440004 | 0.98 | EPHX2 (0.59) | EPHX2ALDH1A1EPHX1SMN1; SMN2CXCR4 | |
| SCHEMBL16440007 | 0.96 | EPHX2 (0.62) | EPHX2ALDH1A1EPHX1SMN1; SMN2CXCR4 | |
| SCHEMBL16439978 | 0.96 | EPHX2 (0.62) | EPHX2ALDH1A1EPHX1SMN1; SMN2CXCR4 | |
| SCHEMBL16439999 | 0.96 | EPHX2 (0.62) | EPHX2ALDH1A1EPHX1SMN1; SMN2CXCR4 | |
| SCHEMBL12482731 | 0.96 | EPHX2 (0.56) | EPHX2ALDH1A1EPHX1SMN1; SMN2CXCR4 | |
| SCHEMBL16439922 | 0.94 | EPHX2 (0.54) | EPHX2ALDH1A1EPHX1SMN1; SMN2CXCR4 | |
| SCHEMBL5510947 | 0.92 | EPHX1 (0.63) | EPHX2ALDH1A1EPHX1SMN1; SMN2CXCR4 | |
| SCHEMBL29952543 | 0.91 | EPHX2 (0.50) | EPHX2ALDH1A1EPHX1SMN1; SMN2CXCR4 | |
| SCHEMBL20389857 | 0.91 | EPHX2 (0.57) | EPHX2ALDH1A1EPHX1SMN1; SMN2CXCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2661268-A2 | INHIBITORS OF POLO-LIKE KINASE | Elan Pharmaceuticals Inc. (US) | 2013-11-13 | — | — | EP | disclosed |
| WO-2012048129-A2 | INHIBITORS OF POLO-LIKE KINASE | ELAN PHARMACEUTICALS, INC. (US) | 2012-04-12 | — | — | WO | disclosed |