Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 7/20 | 0.32 |
| ▸ | PLK2 | Q9NYY3 | 7/20 | 0.32 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2688601 | 1.00 | PLK1 (0.32) | PLK1PLK2PLK3 | |
| SCHEMBL1688656 | 0.88 | PLK1 (0.34) | PLK1PLK2PLK3 | |
| SCHEMBL1289286 | 0.88 | PLK2 (0.46) | PLK1PLK2PLK3 | |
| SCHEMBL2691704 | 0.85 | CD38 (0.31) | — | |
| SCHEMBL2051811 | 0.81 | PLK2 (0.43) | PLK1PLK2PLK3 | |
| SCHEMBL2690159 | 0.78 | PLK2 (0.48) | PLK1PLK2PLK3 | |
| SCHEMBL2691880 | 0.76 | CD38 (0.31) | — | |
| SCHEMBL1289321 | 0.76 | CD38 (0.31) | — | |
| SCHEMBL2345793 | 0.71 | PLK2 (0.58) | PLK1PLK2PLK3 | |
| SCHEMBL5943402 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2661268-A2 | INHIBITORS OF POLO-LIKE KINASE | Elan Pharmaceuticals Inc. (US) | 2013-11-13 | — | — | EP | disclosed |
| WO-2012048129-A2 | INHIBITORS OF POLO-LIKE KINASE | ELAN PHARMACEUTICALS, INC. (US) | 2012-04-12 | — | — | WO | disclosed |