Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 15/20 | 0.72 |
| ▸ | INSR | P06213 | 14/20 | 0.72 |
| ▸ | IGF1R | P08069 | 14/20 | 0.72 |
| ▸ | EGFR | P00533 | 5/20 | 0.70 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.65 |
| ▸ | AURKA | O14965 | 2/20 | 0.65 |
| ▸ | JAK2 | O60674 | 2/20 | 0.65 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.65 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.65 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.65 |
| ▸ | LCK | P06239 | 2/20 | 0.65 |
| ▸ | FES | P07332 | 2/20 | 0.65 |
| ▸ | CSF1R | P07333 | 2/20 | 0.65 |
| ▸ | RET | P07949 | 2/20 | 0.65 |
| ▸ | MET | P08581 | 2/20 | 0.65 |
| ▸ | HCK | P08631 | 2/20 | 0.65 |
| ▸ | ROS1 | P08922 | 2/20 | 0.65 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.65 |
| ▸ | PHKG2 | P15735 | 2/20 | 0.65 |
| ▸ | FER | P16591 | 2/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12780087 | 0.95 | ALK (0.67) | ALKINSRIGF1REGFRCHEK1 | |
| SCHEMBL12892810 | 0.94 | ALK (0.66) | ALKINSRIGF1REGFRCHEK1 | |
| SCHEMBL12780636 | 0.92 | ALK (0.61) | ALKINSRIGF1REGFRCHEK1 | |
| SCHEMBL12728737 | 0.91 | ALK (0.59) | ALKINSRIGF1REGFRCHEK1 | |
| SCHEMBL10207506 | 0.91 | ALK (0.60) | ALKINSRIGF1REGFRCHEK1 | |
| SCHEMBL12780228 | 0.89 | ALK (0.57) | ALKINSRIGF1REGFRCHEK1 | |
| SCHEMBL12728783 | 0.88 | INSR (0.73) | ALKINSRIGF1REGFRCHEK1 | |
| SCHEMBL1911947 | 0.87 | ALK (0.65) | ALKINSRIGF1REGFRCHEK1 | |
| SCHEMBL1911938 | 0.86 | ALK (0.64) | ALKINSRIGF1REGFRCHEK1 | |
| SCHEMBL12729784 | 0.85 | INSR (0.52) | ALKINSRIGF1REGFRPTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7893074-B2 | inhibition of focal adhesion kinase or/and IGF-1 Receptor; for example: 2-[2-(2,5-Dimethoxy-phenylamino)-5-nitro-pyrimidin-4-ylamino]-N-methyl-benzenesulfonamide | NOVARTIS AG (CH) | 2011-02-22 | — | — | US | disclosed |
| US-7893074-B2 | inhibition of focal adhesion kinase or/and IGF-1 Receptor; for example: 2-[2-(2,5-Dimethoxy-phenylamino)-5-nitro-pyrimidin-4-ylamino]-N-methyl-benzenesulfonamide | NOVARTIS AG (CH) | 2011-02-22 | — | — | US | disclosed |
| US-20080132504-A1 | 2, 4-Pyrimidinediamines Useful In The Treatment Of Neoplastic Diseases, Inflammatory And Immune System Disorders | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2008-06-05 | — | — | US | disclosed |
| US-20080132504-A1 | 2, 4-Pyrimidinediamines Useful In The Treatment Of Neoplastic Diseases, Inflammatory And Immune System Disorders | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2008-06-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080132504-A1 | 2, 4-Pyrimidinediamines Useful In The Treatment Of Neoplastic Diseases, Inflammatory And Immune System Disorders | TYMS, TYMP, DPYD | ALK 3200/4885INSR 2899/4885IGF1R 4633/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.